van Veen Anneloes, Shahab Selvi N, Rijfkogel Amber, Vos Margreet C, Saharman Yulia Rosa, Karuniawati Anis, Zelli Silvia, De Lorenzis Desy, Menchinelli Giulia, De Angelis Giulia, Sanguinetti Maurizio, Voor In 't Holt Anne F, Severin Juliëtte A
Department of Medical Microbiology and Infectious Diseases, Erasmus MC University Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands.
Department of Clinical Microbiology, Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia.
Sci Rep. 2025 Jul 21;15(1):26392. doi: 10.1038/s41598-025-10175-y.
Pseudomonas aeruginosa may colonize humans, however, epidemiological data are scarce. Here, we determined overall and body site-specific carriage rates and associated risk factors among healthy individuals and newly admitted patients in three major cities. This cross-sectional study was conducted in Rotterdam (The Netherlands), Rome (Italy), and Jakarta (Indonesia) between 2022-2024. Adult healthy individuals and newly admitted patients were asked to provide throat, navel, and rectal/perianal swabs, and to complete a questionnaire. Univariable and multivariable analyses were performed to determine factors associated with P. aeruginosa carriage. Carriage rates differed significantly between cities (p < 0.001), and were lowest in Rome (healthy individuals 4.8%; patients 6.5%), followed by Rotterdam (healthy individuals 12.0%; patients 12.7%), and Jakarta (healthy individuals 28.6%; patients 24.0%). In carriers from Rotterdam, P. aeruginosa was most often detected in perianal swabs, while mostly in throat swabs among carriers from Rome and Jakarta. P. aeruginosa carriage had a seasonal association in patients from Rotterdam (p = 0.014) and Jakarta (p = 0.020). Among patients from Jakarta, female sex (aOR 1.98, 95% CI 1.02-3.84; p = 0.045) was associated with P. aeruginosa carriage. Overall, P. aeruginosa carriage rates and colonized body sites differ between cities and are likely associated with climate differences. Our findings warrant setting-specific adaptations of screening strategies and surveillance programs.
铜绿假单胞菌可能会在人类中定植，然而，流行病学数据却很匮乏。在此，我们确定了三个主要城市中健康个体和新入院患者的总体及特定身体部位的携带率以及相关风险因素。这项横断面研究于2022年至2024年期间在鹿特丹（荷兰）、罗马（意大利）和雅加达（印度尼西亚）开展。成年健康个体和新入院患者被要求提供咽喉、肚脐以及直肠/肛周拭子，并完成一份问卷。进行单变量和多变量分析以确定与铜绿假单胞菌携带相关的因素。不同城市之间的携带率存在显著差异（p < 0.001），罗马的携带率最低（健康个体为4.8%；患者为6.5%），其次是鹿特丹（健康个体为12.0%；患者为12.7%），雅加达最高（健康个体为28.6%；患者为24.0%）。在鹿特丹的携带者中，铜绿假单胞菌最常在肛周拭子中被检测到，而在罗马和雅加达的携带者中则大多在咽喉拭子中被检测到。在鹿特丹（p = 0.014）和雅加达（p = 0.020）的患者中，铜绿假单胞菌携带具有季节性关联。在雅加达的患者中，女性（调整后比值比1.98，95%置信区间1.02 - 3.84；p = 0.045）与铜绿假单胞菌携带相关。总体而言，不同城市之间铜绿假单胞菌的携带率和定植身体部位有所不同，并且可能与气候差异有关。我们的研究结果表明筛查策略和监测计划需要根据具体情况进行调整。
