Wu Yun, Wang Aixin, Qu Jinghan, Ma Ruirui, Kang Wei, Liu Yali, Xu Yingchun
Department of Laboratory Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Graduate School, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.
Microbiol Spectr. 2025 Jul;13(7):e0028725. doi: 10.1128/spectrum.00287-25. Epub 2025 Jun 11.
The aim of the study was to compare antimicrobial susceptibility between mucoid and non-mucoid and its guiding value for antibiotic therapy. A retrospective review was conducted on the sources of isolates, patient information, antimicrobial susceptibility results, and antimicrobial usage records for mucoid and non-mucoid isolates spanning from 2021 to 2023, comparing the differences between the two types. Additionally, infection cases of mucoid and non-mucoid were selected for in-depth analysis of their treatment courses, evaluating the guiding value of antimicrobial susceptibility results for antimicrobial therapy. We collected 1,443 non-mucoid and 342 mucoid . Our findings revealed that mucoid was predominantly found in respiratory tract specimens, while non-mucoid was primarily isolated from a broader range of specimen sources. Regarding antimicrobial susceptibility, mucoid exhibited notably lower levels of resistance compared to their non-mucoid counterparts, except for ciprofloxacin, levofloxacin, and cefepime. The most frequently prescribed drugs for mucoid were levofloxacin and ceftazidime, whereas for non-mucoid ceftazidime and meropenem were more frequently used. A total of 42 non-mucoid cases and 36 mucoid cases were further analyzed, which were isolated from hospitalized patients with a confirmed diagnosis of monomicrobial infection. The analysis of case information revealed that 90.2% of non-mucoid infections and 94.4% of mucoid infections showed consistency between antimicrobial susceptibility and outcomes. Our results revealed differences in demographic and clinical characteristics, antimicrobial susceptibility, and selection of antimicrobial agents between mucoid and non-mucoid . The findings will help optimize prognosis and combat the challenges posed by infections.
This study represents a large-scale comparative research conducted over two years at a tertiary hospital in China, involving 1,443 non-mucoid and 342 mucoid strains. We found significant differences between mucoid and non-mucoid . infections in terms of gender, antimicrobial susceptibility test, and the selection of antimicrobial agents. Specifically, mucoid infections were predominantly observed in females and were mainly associated with respiratory tract infections. Moreover, the isolates with mucoid phenotype exhibited higher susceptibility to most antimicrobial agents compared to non-mucoid isolates. According to the data of the pharmacy department, we found the most frequently prescribed drugs for mucoid were levofloxacin and ceftazidime, whereas for non-mucoid , ceftazidime and meropenem were more frequently used. The analysis of case information revealed that no matter whether in mucoid or non-mucoid , the in vitro antimicrobial susceptibility test results were in good agreement with the therapeutic outcomes.
本研究旨在比较黏液型和非黏液型菌株之间的抗菌药敏情况及其对抗生素治疗的指导价值。对2021年至2023年期间黏液型和非黏液型菌株的分离来源、患者信息、抗菌药敏结果及抗菌药物使用记录进行回顾性分析，比较两者差异。此外，选取黏液型和非黏液型感染病例深入分析其治疗过程，评估抗菌药敏结果对抗菌治疗的指导价值。我们收集了1443株非黏液型菌株和342株黏液型菌株。研究结果显示，黏液型菌株主要存在于呼吸道标本中，而非黏液型菌株主要从更广泛的标本来源中分离得到。在抗菌药敏方面，除环丙沙星、左氧氟沙星和头孢吡肟外，黏液型菌株的耐药水平明显低于非黏液型菌株。黏液型菌株最常用的药物是左氧氟沙星和头孢他啶，而非黏液型菌株更常用头孢他啶和美罗培南。对42例非黏液型病例和36例黏液型病例进行了进一步分析，这些病例均来自确诊为单一微生物感染的住院患者。病例信息分析显示，90.2%的非黏液型感染和94.4%的黏液型感染在抗菌药敏与治疗结果之间表现出一致性。我们的结果揭示了黏液型和非黏液型菌株在人口统计学和临床特征、抗菌药敏以及抗菌药物选择方面的差异。这些发现将有助于优化预后并应对由[菌株名称]感染带来的挑战。
本研究是在中国一家三级医院进行的为期两年的大规模比较研究，涉及1443株非黏液型菌株和342株黏液型菌株。我们发现黏液型和非黏液型菌株在性别、抗菌药敏试验以及抗菌药物选择方面存在显著差异。具体而言，黏液型感染主要在女性中观察到，且主要与呼吸道感染相关。此外，与非黏液型菌株相比，具有黏液型表型的分离株对大多数抗菌药物表现出更高的敏感性。根据药房数据，我们发现黏液型菌株最常用的药物是左氧氟沙星和头孢他啶，而非黏液型菌株更常用头孢他啶和美罗培南。病例信息分析显示，无论在黏液型还是非黏液型菌株中，体外抗菌药敏试验结果与治疗结果均高度一致。
