Dutrillaux B, Viegas-Pequignot E, Prod'homme M, Sportes M
Mutat Res. 1985 Nov-Dec;152(2-3):197-203. doi: 10.1016/0027-5107(85)90061-2.
The quantitative analysis of the chromosome rearrangements detected in 2128 R-banded metaphases, obtained from gamma-irradiated human lymphocytes after 48 to 96 h in culture is reported. Depending on the culture time, and possibly on the dose of radiation (from 1 to 3 Gy), the most frequent type of rearrangement was either dicentrics or reciprocal translocations. In first generation mitoses, the frequency of cells without rearrangement ranged from 0.66 to 0.18, and the mean number of rearranged chromosomes per cell from 0.79 to 3.28. The dose-response curve follows a quadratic function for dicentric aberration yields, but not for other rearrangements.
报告了对2128个经R显带处理的中期染色体进行的定量分析，这些中期染色体来自于在培养48至96小时后经γ射线照射的人类淋巴细胞。根据培养时间，以及可能还取决于辐射剂量（1至3戈瑞），最常见的重排类型要么是双着丝粒染色体，要么是相互易位。在第一代有丝分裂中，无重排细胞的频率范围为0.66至0.18，每个细胞重排染色体的平均数为0.79至3.28。双着丝粒畸变产额的剂量反应曲线遵循二次函数，但其他重排则不然。
