2型糖尿病患者同时进行持续有氧运动和短休息抗阻运动训练对代谢生物标志物的影响：一项系统评价和荟萃分析

Effects of concurrent continuous aerobic and short rest resistance exercise training on metabolic biomarkers in type 2 diabetes patients: a systematic review and meta-analysis.

作者信息

Amare Friew, Kiflu Alemmebrat, Taddese Aschenaki

机构信息

Department of Sports Science and Physical Education, College of Education and Language Studies, Addis Ababa University, Addis Ababa, Ethiopia.

出版信息

Diabetol Metab Syndr. 2025 Jul 21;17(1):290. doi: 10.1186/s13098-025-01838-x.

DOI:10.1186/s13098-025-01838-x

PMID:40691799

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12278580/

Abstract

OBJECTIVE

This study aimed to systematically evaluate the impact of a 12-week concurrent training program combining continuous aerobic exercise and short-rest resistance training on metabolic biomarkers in type 2 diabetes mellitus (T2DM) patients through a meta-analysis of the available evidence.

METHODS

A literature search was performed in Google Scholar, PubMed, Web of Science, Science Direct and Cochrane covering databases for relevant randomized controlled trials, and studies were included and individually assessed according to the Cochrane risk of bias tool in the Cochrane Systematic Assessor’s Handbook. The data were analysed via Stata version 17 analysis software to analyse and process the data.

RESULTS

A comprehensive review and analysis were conducted on 11 carefully selected articles, encompassing a total of 438 participants across both the experimental and control groups. The results of the meta-analysis revealed that concurrent training combining continuous aerobic exercise and a short-rest resistance training program reduced HbA1c (SMD = − 0.53, 95% CI = [− 0.98, − 0.07], = 0.03; HOMA-IR (SMD = − 0.80, 95% CI = [− 1.24, − 0.35], < 0.001); HDL-C (SMD = 0.30, 95% CI = [0.03, 0.57], = 0.03); TG (SMD = -0.78, 95% CI = [-1.33, -0.23], = 0.01); and TC (SMD = -0.37, 95% CI = [-0.63, -0.10], = 0.01) in type 2 diabetes patients.

CONCLUSION

These findings provide strong evidence supporting the beneficial effects of 12 weeks of continuous aerobic exercise combined with short-rest resistance training within the same session on metabolic health markers such as HbA1c, HOMA-IR, HDL-C, TG and TC in individuals with T2DM. The review underscores the need for additional randomized controlled trials to investigate optimal exercise sequencing, extended intervention durations, and better control of confounding variables to deepen our understanding of the efficacy of concurrent training in this population.

SUPPLEMENTARY INFORMATION

The online version contains supplementary material available at 10.1186/s13098-025-01838-x.

摘要

目的

本研究旨在通过对现有证据的荟萃分析，系统评估一项为期12周的将持续有氧运动与短休息抗阻训练相结合的联合训练计划对2型糖尿病（T2DM）患者代谢生物标志物的影响。

方法

在谷歌学术、PubMed、科学网、Science Direct和Cochrane等数据库中进行文献检索，查找相关随机对照试验，并根据《Cochrane系统评价员手册》中的Cochrane偏倚风险工具对纳入的研究进行单独评估。通过Stata 17分析软件对数据进行分析和处理。

结果

对11篇精心挑选的文章进行了全面回顾和分析，实验组和对照组共有438名参与者。荟萃分析结果显示，持续有氧运动与短休息抗阻训练相结合的联合训练可降低2型糖尿病患者的糖化血红蛋白（SMD = -0.53，95%CI = [-0.98, -0.07]，P = 0.03）、胰岛素抵抗指数（SMD = -0.80，95%CI = [-1.24, -0.35]，P < 0.001）、高密度脂蛋白胆固醇（SMD = 0.30，95%CI = [0.03, 0.57]，P = 0.03）、甘油三酯（SMD = -0.78，95%CI = [-1.33, -0.23]，P = 0.01）和总胆固醇（SMD = -0.37，95%CI = [-0.63, -0.10]，P = 0.01）。

结论

这些发现提供了有力证据，支持在同一训练时段内进行12周持续有氧运动与短休息抗阻训练相结合对T2DM患者糖化血红蛋白（HbA1c）、胰岛素抵抗指数（HOMA-IR）、高密度脂蛋白胆固醇（HDL-C）、甘油三酯（TG）和总胆固醇（TC）等代谢健康指标有益。该综述强调需要更多随机对照试验来研究最佳运动顺序、延长干预时间以及更好地控制混杂变量，以加深我们对该人群联合训练效果的理解。