Jaisue Jirapat, Sun Jinkun, Marufah Nur Laili, Itagaki Masashi, Isobe Naoki
Graduate School of Integrated Sciences for Life, Hiroshima University, Higashi-Hiroshima, Hiroshima, Japan.
Faculty of Animal Science, Universitas Gadjah Mada, Yogyakarta, Indonesia.
Anim Sci J. 2025 Jan-Dec;96(1):e70085. doi: 10.1111/asj.70085.
We aimed to clarify antimicrobial component (AMC) dynamics during the dry period in dairy cows and determine the impacts of varying somatic cell count (SCC) at the onset of the dry period on the subsequent changes in AMC concentrations in milk. Milk samples obtained from Holstein dairy cows were categorized into low-SCC and high-SCC groups. AMC concentrations in milk were measured at four time points: (1) Onset of the dry period, (2) before calving, (3) immediately after calving, and (4) 1 week postpartum. In the low-SCC group, SCC and lingual antimicrobial peptide increased prepartum but decreased 1 week postpartum. Milk lactoperoxidase and lactoferrin concentrations increased prepartum but declined after calving, while cathelicidin-7, S100A7, and S100A8 concentrations increased after calving compared to those prepartum in both groups. S100A7 concentrations in the low-SCC group were significantly higher than those in the high-SCC group prepartum and immediately after calving. However, S100A8 concentrations in the low-SCC group were significantly lower than those in the high-SCC group prepartum and 1 week postpartum. These results suggest that some AMCs were elevated after the onset of the dry period and immediately after calving and highlight the importance of mitigating inflammation in the mammary glands before the onset of the dry period.
我们旨在阐明奶牛干奶期抗菌成分（AMC）的动态变化，并确定干奶期开始时不同体细胞计数（SCC）对随后牛奶中AMC浓度变化的影响。从荷斯坦奶牛采集的牛奶样本被分为低SCC组和高SCC组。在四个时间点测量牛奶中的AMC浓度：（1）干奶期开始时，（2）产犊前，（3）产犊后立即，以及（4）产后1周。在低SCC组中，SCC和舌抗菌肽在产前增加，但在产后1周下降。牛奶中的乳过氧化物酶和乳铁蛋白浓度在产前增加，但在产犊后下降，而两组中cathelicidin-7、S100A7和S100A8浓度在产犊后均高于产前。低SCC组中S100A7浓度在产前和产犊后立即显著高于高SCC组。然而，低SCC组中S100A8浓度在产前和产后1周显著低于高SCC组。这些结果表明，一些AMC在干奶期开始后和产犊后立即升高，并突出了在干奶期开始前减轻乳腺炎症的重要性。
