Yuanyue Li, Qian Hu, Ling Liu, Liufeng Yang, Jing Ge, Xiaomei Wu
Department of Gynecology, The First People's Hospital of Yunnan Province, Kunming, China.
The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, China.
Front Cell Infect Microbiol. 2025 Jul 7;15:1526063. doi: 10.3389/fcimb.2025.1526063. eCollection 2025.
Endometriosis is widely recognized as a chronic, inflammatory, and heterogeneous condition that can manifest in various anatomical locations within females. It is marked by estrogen-driven cycles of bleeding, cell proliferation, and fibrosis involving ectopic endometrial glands and stroma cells located outside the uterus. The limited understanding of its etiology and complex pathogenesis has created obstacles in achieving early diagnosis and developing effective treatments with minimal side effects. Consequently, endometriosis requires more in-depth research to unravel its pathogenesis. The gut microbiota, a key player in chronic diseases, significantly influences bodily metabolism and immune regulation. Emerging evidence links the gut microbiota to inflammation, estrogen metabolism, and immune responses-key factors in the onset and progression of endometriosis. This review examines the various mechanisms through which endometriosis and the gut microbiota interact, aiming to inspire new strategies for preventing and early treating endometriosis.
子宫内膜异位症被广泛认为是一种慢性、炎症性和异质性疾病，可在女性体内的各种解剖位置表现出来。其特征是由雌激素驱动的出血、细胞增殖和纤维化循环，涉及位于子宫外的异位子宫内膜腺体和间质细胞。对其病因和复杂发病机制的了解有限，在实现早期诊断和开发副作用最小的有效治疗方法方面造成了障碍。因此，子宫内膜异位症需要更深入的研究来阐明其发病机制。肠道微生物群是慢性疾病的关键因素，对身体代谢和免疫调节有显著影响。新出现的证据将肠道微生物群与炎症、雌激素代谢和免疫反应联系起来，这些是子宫内膜异位症发生和发展的关键因素。本综述探讨了子宫内膜异位症与肠道微生物群相互作用的各种机制，旨在激发预防和早期治疗子宫内膜异位症的新策略。
