• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

探讨白细胞介素-8、白细胞介素-10、患者自述疼痛及身体活动对子宫内膜异位症严重程度的影响。

Exploring the Influence of IL-8, IL-10, Patient-Reported Pain, and Physical Activity on Endometriosis Severity.

作者信息

Nati Ionel Daniel, Malutan Andrei, Ciortea Razvan, Oancea Mihaela, Bucuri Carmen, Roman Maria, Ormindean Cristina, Milon Alexandra Gabriela, Mihu Dan

机构信息

2nd Department of Obstetric and Ginecology, "Iuliu Hatieganu" University of Medicine and Pharmacy, 400610 Cluj-Napoca, Romania.

Emergency Military Clinical Hospital "Dr Constantin Papilian", 400610 Cluj-Napoca, Romania.

出版信息

Diagnostics (Basel). 2024 Aug 21;14(16):1822. doi: 10.3390/diagnostics14161822.

DOI:10.3390/diagnostics14161822
PMID:39202309
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11353965/
Abstract

Endometriosis is known to be a chronic, debilitating disease. The pathophysiological mechanisms of endometriosis development include local chronic inflammation and a certain degree of local immune deficit. We investigated the relationship between the endometriosis severity, IL-8, IL-10, BDNF, VEGF-A serum and tissue levels, patient-related pain, and physical activity in a cohort of 46 patients diagnosed with endometriosis who underwent surgery. The same panel of biomarkers was investigated in a control group of 44 reproductive-aged patients with non-endometriotic gynecological pathology who underwent surgical intervention. Our data show a high statistical significance between tissue expression of IL-8, IL-10, patient-related pain, and the severity of endometriosis. No relationship was identified between serum or tissue levels of VEGF-A and BDNF and the severity of endometriosis. These results validate the presence of local chronic inflammation and immune deficit, thereby creating, alongside other studies in the field, an opportunity for the development of innovative and personalized treatment approaches in endometriosis.

摘要

子宫内膜异位症是一种慢性、使人衰弱的疾病。子宫内膜异位症发生发展的病理生理机制包括局部慢性炎症和一定程度的局部免疫缺陷。我们在46例接受手术的诊断为子宫内膜异位症的患者队列中，研究了子宫内膜异位症严重程度、白细胞介素-8（IL-8）、白细胞介素-10（IL-10）、脑源性神经营养因子（BDNF）、血管内皮生长因子-A（VEGF-A）血清和组织水平、患者相关疼痛及身体活动之间的关系。在44例接受手术干预的患有非子宫内膜异位症妇科疾病的育龄期对照患者中，对同一组生物标志物进行了研究。我们的数据显示，IL-8、IL-10的组织表达、患者相关疼痛与子宫内膜异位症严重程度之间具有高度统计学意义。未发现VEGF-A和BDNF的血清或组织水平与子宫内膜异位症严重程度之间存在关联。这些结果证实了局部慢性炎症和免疫缺陷的存在，从而与该领域的其他研究一起，为子宫内膜异位症创新和个性化治疗方法的开发创造了机会。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bde/11353965/1236e45b5c4c/diagnostics-14-01822-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bde/11353965/cd0dc2886e68/diagnostics-14-01822-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bde/11353965/1654150a8313/diagnostics-14-01822-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bde/11353965/23ac2fe3eda7/diagnostics-14-01822-g003a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bde/11353965/bb2f5ae6dbd0/diagnostics-14-01822-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bde/11353965/0a479ed9bb9a/diagnostics-14-01822-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bde/11353965/1236e45b5c4c/diagnostics-14-01822-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bde/11353965/cd0dc2886e68/diagnostics-14-01822-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bde/11353965/1654150a8313/diagnostics-14-01822-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bde/11353965/23ac2fe3eda7/diagnostics-14-01822-g003a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bde/11353965/bb2f5ae6dbd0/diagnostics-14-01822-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bde/11353965/0a479ed9bb9a/diagnostics-14-01822-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bde/11353965/1236e45b5c4c/diagnostics-14-01822-g006.jpg

相似文献

1
Exploring the Influence of IL-8, IL-10, Patient-Reported Pain, and Physical Activity on Endometriosis Severity.探讨白细胞介素-8、白细胞介素-10、患者自述疼痛及身体活动对子宫内膜异位症严重程度的影响。
Diagnostics (Basel). 2024 Aug 21;14(16):1822. doi: 10.3390/diagnostics14161822.
2
The expression and significance of leukemia inhibitory factor, interleukin-6 and vascular endothelial growth factor in Chinese patients with endometriosis.中国子宫内膜异位症患者白血病抑制因子、白细胞介素 6 和血管内皮生长因子的表达及意义。
Arch Gynecol Obstet. 2021 Jul;304(1):163-170. doi: 10.1007/s00404-021-05980-5. Epub 2021 Feb 8.
3
IL-10 is not anti-fibrotic but pro-fibrotic in endometriosis: IL-10 treatment of endometriotic stromal cells in vitro promotes myofibroblast proliferation and collagen type I protein expression.白细胞介素-10在子宫内膜异位症中并非抗纤维化而是促纤维化：体外对子宫内膜异位症基质细胞进行白细胞介素-10处理可促进肌成纤维细胞增殖及I型胶原蛋白表达。
Hum Reprod. 2023 Jan 5;38(1):14-29. doi: 10.1093/humrep/deac248.
4
Serum concentrations of IL-16 and its genetic polymorphism rs4778889 affect the susceptibility and severity of endometriosis in Nigerian women.血清中白细胞介素-16 及其遗传多态性 rs4778889 的浓度会影响尼日利亚女性子宫内膜异位症的易感性和严重程度。
BMC Womens Health. 2023 May 11;23(1):253. doi: 10.1186/s12905-023-02362-8.
5
Persistent activation of signal transducer and activator of transcription 3 via interleukin-6 trans-signaling is involved in fibrosis of endometriosis.白细胞介素 6 转导信号通过信号转导子和转录激活子 3 的持续激活参与子宫内膜异位症的纤维化。
Hum Reprod. 2022 Jun 30;37(7):1489-1504. doi: 10.1093/humrep/deac098.
6
Surgical removal of endometriotic lesions alters local and systemic proinflammatory cytokines in endometriosis patients.手术切除子宫内膜异位症病灶可改变子宫内膜异位症患者局部和全身的促炎细胞因子。
Fertil Steril. 2016 Apr;105(4):968-977.e5. doi: 10.1016/j.fertnstert.2015.11.047. Epub 2015 Dec 14.
7
[Vascular endothelial growth factor is up-regulated by leukemia inhibitory factor and interleukin-6 in human endometriotic stromal cells].血管内皮生长因子在人子宫内膜异位症基质细胞中被白血病抑制因子和白细胞介素-6上调
Zhonghua Fu Chan Ke Za Zhi. 2019 May 25;54(5):324-329. doi: 10.3760/cma.j.issn.0529-567x.2019.05.007.
8
Blood biomarkers for the non-invasive diagnosis of endometriosis.用于子宫内膜异位症无创诊断的血液生物标志物。
Cochrane Database Syst Rev. 2016 May 1;2016(5):CD012179. doi: 10.1002/14651858.CD012179.
9
BDNF and TrKB expression levels in patients with endometriosis and their associations with dysmenorrhoea.子宫内膜异位症患者 BDNF 和 TrKB 表达水平及其与痛经的关系。
J Ovarian Res. 2022 Mar 17;15(1):35. doi: 10.1186/s13048-022-00963-9.
10
Interleukin-33 modulates inflammation in endometriosis.白细胞介素-33 调节子宫内膜异位症中的炎症反应。
Sci Rep. 2017 Dec 20;7(1):17903. doi: 10.1038/s41598-017-18224-x.

引用本文的文献

1
Impact of gut microbiota on endometriosis: linking physical injury to mental health.肠道微生物群对子宫内膜异位症的影响：将身体损伤与心理健康联系起来。
Front Cell Infect Microbiol. 2025 Jul 7;15:1526063. doi: 10.3389/fcimb.2025.1526063. eCollection 2025.
2
Dyspareunia and Biomarkers: A Case Study of Sexual Dysfunction in Moderate Endometriosis.性交疼痛与生物标志物：中度子宫内膜异位症性功能障碍的病例研究
Int J Mol Sci. 2024 Dec 27;26(1):162. doi: 10.3390/ijms26010162.

本文引用的文献

1
Chronic low-grade inflammation and ovarian dysfunction in women with polycystic ovarian syndrome, endometriosis, and aging.多囊卵巢综合征、子宫内膜异位症和衰老女性的慢性低度炎症与卵巢功能障碍。
Front Endocrinol (Lausanne). 2023 Dec 13;14:1324429. doi: 10.3389/fendo.2023.1324429. eCollection 2023.
2
Endometriosis and Adolescence: The Impact of Dysmenorrhea.子宫内膜异位症与青春期：痛经的影响
J Clin Med. 2023 Aug 29;12(17):5624. doi: 10.3390/jcm12175624.
3
IL-8 and IL-12p70 are associated with pelvic pain among infertile women with endometriosis.
白细胞介素-8 和白细胞介素-12p70 与子宫内膜异位症不孕女性的盆腔痛相关。
Pain Med. 2023 Nov 2;24(11):1262-1269. doi: 10.1093/pm/pnad080.
4
Association between polymorphisms of cytokine genes and endometriosis: A comprehensive systematic review and meta-analysis.细胞因子基因多态性与子宫内膜异位症之间的关联：一项全面的系统评价和荟萃分析。
J Reprod Immunol. 2023 Aug;158:103969. doi: 10.1016/j.jri.2023.103969. Epub 2023 May 25.
5
The dysregulation of leukemia inhibitory factor and its implications for endometriosis pathophysiology.白血病抑制因子失调及其对子宫内膜异位症病理生理学的影响。
Front Immunol. 2023 Mar 23;14:1089098. doi: 10.3389/fimmu.2023.1089098. eCollection 2023.
6
The genetic basis of endometriosis and comorbidity with other pain and inflammatory conditions.子宫内膜异位症及其与其他疼痛和炎症性疾病并存的遗传基础。
Nat Genet. 2023 Mar;55(3):423-436. doi: 10.1038/s41588-023-01323-z. Epub 2023 Mar 13.
7
The Main Theories on the Pathogenesis of Endometriosis.子宫内膜异位症发病机制的主要理论。
Int J Mol Sci. 2023 Feb 21;24(5):4254. doi: 10.3390/ijms24054254.
8
Single-cell transcriptome analysis reveals endometrial immune microenvironment in minimal/mild endometriosis.单细胞转录组分析揭示了微小/轻度子宫内膜异位症的子宫内膜免疫微环境。
Clin Exp Immunol. 2023 Jun 5;212(3):285-295. doi: 10.1093/cei/uxad029.
9
From Retrograde Menstruation to Endometrial Determinism and a Brave New World of "Root Treatment" of Endometriosis: Destiny or a Fanciful Utopia?从逆行性月经到子宫内膜决定论，以及子宫内膜异位症“根源治疗”的崭新世界：是命运还是幻想的乌托邦？
Biomolecules. 2023 Feb 9;13(2):336. doi: 10.3390/biom13020336.
10
A long-acting anti-IL-8 antibody improves inflammation and fibrosis in endometriosis.一种长效抗 IL-8 抗体可改善子宫内膜异位症的炎症和纤维化。
Sci Transl Med. 2023 Feb 22;15(684):eabq5858. doi: 10.1126/scitranslmed.abq5858.