Ma Yucong, Lin Wenying, Zheng Haoqi, Wang Yang, Cui Jingjing, Liu Li
Department of Pediatric Respiratory, Children's Medical Center, The First Hospital of Jilin University, Changchun, China.
Department of Pediatrics, Yanbian University Hospital, Yanji, Jilin, China.
Front Pediatr. 2025 Jul 7;13:1567548. doi: 10.3389/fped.2025.1567548. eCollection 2025.
Asthma is the most common chronic respiratory disease in childhood, and effective control of airway inflammation is crucial in its management. Fractional exhaled nitric oxide (FeNO) and fractional nasally exhaled nitric oxide (FnNO) are non-invasive biomarkers that reflect airway inflammation. This study aimed to evaluate the role of FeNO and FnNO in assessing asthma control status and to explore their correlation with pulmonary function parameters in pediatric patients.
This was a retrospective observational study. A total of 88 children with asthma were classified into three groups based on Childhood Asthma Control Test (C-ACT) scores: the control group, the partial control group, and the poor control group. FeNO, FnNO, and pulmonary function tests were measured and compared across the three groups. The correlation between FeNO/FnNO levels and pulmonary function indices was also analyzed.
The levels of FeNO and FnNO were significantly higher in the poor control group compared with those in the partial control and the control groups ( < 0.05). As asthma control improved, forced vital capacity (FVC) showed a statistically significant increase. The forced expiratory volume in one second (FEV₁), maximal expiratory flow at 50% of FVC (MEF), and mean mid-expiratory flow (MMEF) values in the poor control group were significantly lower than those in the other two groups, and PEF was significantly reduced compared with that in the control group. However, no significant correlations were found between FeNO or FnNO levels and any of the pulmonary function parameters.
Although FeNO and FnNO levels differed significantly among asthma control groups, no significant correlation was observed between these biomarkers and pulmonary function parameters. These findings suggest that FeNO and FnNO should be used together to assess asthma control status, but they may not directly reflect changes in pulmonary function in children with asthma.
哮喘是儿童期最常见的慢性呼吸道疾病，有效控制气道炎症对其治疗至关重要。呼出一氧化氮分数（FeNO）和经鼻呼出一氧化氮分数（FnNO）是反映气道炎症的非侵入性生物标志物。本研究旨在评估FeNO和FnNO在评估哮喘控制状态中的作用，并探讨它们与儿科患者肺功能参数的相关性。
这是一项回顾性观察研究。根据儿童哮喘控制测试（C-ACT）评分，将88例哮喘儿童分为三组：对照组、部分控制组和控制不佳组。对三组进行FeNO、FnNO和肺功能测试并比较。还分析了FeNO/FnNO水平与肺功能指标之间的相关性。
与部分控制组和对照组相比，控制不佳组的FeNO和FnNO水平显著更高（<0.05）。随着哮喘控制的改善，用力肺活量（FVC）有统计学显著增加。控制不佳组的一秒用力呼气容积（FEV₁）、FVC 50%时的最大呼气流量（MEF）和平均呼气中期流量（MMEF）值显著低于其他两组，与对照组相比，呼气峰值流量（PEF）显著降低。然而，未发现FeNO或FnNO水平与任何肺功能参数之间存在显著相关性。
尽管哮喘控制组之间FeNO和FnNO水平差异显著，但未观察到这些生物标志物与肺功能参数之间存在显著相关性。这些发现表明，FeNO和FnNO应联合用于评估哮喘控制状态，但它们可能无法直接反映哮喘儿童的肺功能变化。
