携带双链RNA Totivirus病毒LRV1的原型的混合参考基因组组装。
Hybrid reference genome assembly for the archetypal bearing the dsRNA totivirus LRV1.
作者信息
Myler Peter J, Ramasamy Gowthaman, Warren Wesley C, Dobson Deborah E, Beverley Stephen M
机构信息
Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, USA.
Department of Pediatrics, University of Washington, Seattle, Washington, USA.
出版信息
Microbiol Resour Announc. 2025 Aug 14;14(8):e0099222. doi: 10.1128/mra.00992-22. Epub 2025 Jul 22.
Abstract
We report a high-quality hybrid genome assembly and annotation for a ) line (M4147) expressing a firefly luciferase reporter gene and bearing the totivirus LRV1 strongly implicated in parasite hypervirulence. This reference genome should facilitate the study of infectivity and pathogenesis of cutaneous and severe leishmaniasis.
摘要
我们报告了针对一株表达萤火虫荧光素酶报告基因且携带与寄生虫高毒力密切相关的全病毒LRV1的品系（M4147）的高质量混合基因组组装和注释。该参考基因组应有助于研究皮肤利什曼病和严重利什曼病的感染性和发病机制。
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