Ravikumar Manish, Uvarajan Deenathayalan, Durairaj Brindha
Department of Biochemistry, PSG College of Arts & Science, Coimbatore, India.
Neurochem Res. 2025 Jul 22;50(4):244. doi: 10.1007/s11064-025-04489-6.
The interaction between immune system dysfunction and neuroinflammation is crucial for the development and progression of epilepsy. This study investigates the complex relationships between immune responses and the onset of epileptic seizures and highlights the influence of neuroinflammatory processes on neuronal integrity and seizure frequency. Key factors such as glial cell activation, release of pro-inflammatory cytokines, and disruption of the blood-brain barrier (BBB) are being investigated for their roles in immune-mediated neurological disorders. The review examines novel therapeutic approaches targeting neuroinflammatory pathways. It highlights their potential to reduce seizure onset and development while addressing challenges in translating research into clinical practice. This study aims to elucidate these pathways, address knowledge gaps and explore novel options for epilepsy treatment.
免疫系统功能障碍与神经炎症之间的相互作用对于癫痫的发生和发展至关重要。本研究调查了免疫反应与癫痫发作起始之间的复杂关系，并强调了神经炎症过程对神经元完整性和癫痫发作频率的影响。正在研究诸如胶质细胞活化、促炎细胞因子释放和血脑屏障（BBB）破坏等关键因素在免疫介导的神经疾病中的作用。该综述探讨了针对神经炎症途径的新型治疗方法。它强调了这些方法在减少癫痫发作起始和发展方面的潜力，同时也指出了将研究转化为临床实践所面临的挑战。本研究旨在阐明这些途径，填补知识空白，并探索癫痫治疗的新选择。
