硫代苹果酸金钠对急性中毒性肝炎的作用
[Effect of sodium aurothiomalate in acute toxic hepatitis].
作者信息
Korolenko T A, Shkurupiĭ V A, Subbotin V M, Iakobson G S
出版信息
Biull Eksp Biol Med. 1977 May;83(5):539-42.
PMID:406945
Abstract
The effect of lysosomotropic agent--sodium aurothiomalate on liver damage and lysosomal changes during acute toxic hepatitis was studied. Combined administration of sodium aurothiomalete led to less extensive necrosis and to widening dystrophic areas in the hepatic parenchyma. Solubilization of the acid RNA-ase activity was decreased, and nonsedimentable activities of beta-galactosidase, cathepsin D were the same as in acute CCl4-hepatitis.
摘要
研究了溶酶体亲和剂硫代苹果酸金钠对急性中毒性肝炎期间肝脏损伤和溶酶体变化的影响。联合给予硫代苹果酸金钠可使肝实质中的坏死范围减小，营养不良区域扩大。酸性RNA酶活性的溶解作用降低，β-半乳糖苷酶、组织蛋白酶D的非沉降活性与急性四氯化碳性肝炎相同。
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