Heniche Yaniss, Abikhzer Gad, McPherson Victor
Department of Nuclear Medicine.
Department of Diagnostic Radiology, Division of Nuclear Medicine, Jewish General Hospital.
Clin Nucl Med. 2025 Nov 1;50(11):1053-1054. doi: 10.1097/RLU.0000000000006062. Epub 2025 Jul 21.
Prostate-specific membrane antigen (PSMA)-targeted PET agents are a mainstay in staging high-risk prostate cancer. Nevertheless, PSMA expression is not exclusive to prostate cancer and is present in various neoplasms and inflammatory conditions. We report a case of biopsy-proven follicular lymphoma positive on PSMA PET/CT originally performed for staging of prostate cancer in a 66-year-old patient. This case highlights the potential pitfall of lymphoma mimicking prostate cancer nodal metastasis on PSMA PET/CT and the importance of careful evaluation of distribution and uptake of lymph nodes when assessing PSMA PET/CT studies to distinguish lymphoma from prostate cancer metastases.
前列腺特异性膜抗原（PSMA）靶向PET显像剂是高危前列腺癌分期的主要手段。然而，PSMA表达并非前列腺癌所特有，在各种肿瘤和炎症性疾病中也可出现。我们报告1例经活检证实的滤泡性淋巴瘤病例，该患者为66岁男性，最初因前列腺癌分期而行PSMA PET/CT检查，结果呈阳性。该病例凸显了PSMA PET/CT上淋巴瘤酷似前列腺癌淋巴结转移的潜在陷阱，以及在评估PSMA PET/CT检查以区分淋巴瘤与前列腺癌转移时仔细评估淋巴结分布和摄取情况的重要性。
