N6-甲基腺嘌呤修饰的RNA与DNA损伤修复的相互作用
The crosstalk of mA-modified RNA with DNA damage repair.
作者信息
Qu Fei, Liu Yuan
机构信息
Biochemistry Ph.D. Program, Florida International University, 11200 S.W. 8th Street, Miami, FL 33199.
Biochemistry Ph.D. Program, Florida International University, 11200 S.W. 8th Street, Miami, FL 33199; Department of Chemistry and Biochemistry, Florida International University, 11200 S.W. 8th Street, Miami, FL 33199; Biomolecular Sciences Institute, Florida International University, 11200 S.W. 8th Street, Miami, FL 33199.
出版信息
Trends Biochem Sci. 2025 Jul 21. doi: 10.1016/j.tibs.2025.06.012.
N-methyladenosine (mA) is the most abundant epitranscriptomic mark on mRNA and plays crucial roles in gene expression, cell differentiation, stress responses, and cancer and neurodegenerative diseases. Recent studies have further revealed a new role of mA-modified coding and noncoding RNAs in regulating DNA repair and modulating genome stability. In this review, we first discuss the roles of mA modification in regulating RNA stability and splicing of DNA repair genes, as well as its roles in guiding DNA repair. We then discuss the crosstalk between mA-modified RNA and DNA damage and repair, highlighting several outstanding questions.
N-甲基腺苷（mA）是mRNA上最丰富的表观转录组标记，在基因表达、细胞分化、应激反应以及癌症和神经退行性疾病中发挥着关键作用。最近的研究进一步揭示了mA修饰的编码和非编码RNA在调节DNA修复和维持基因组稳定性方面的新作用。在这篇综述中，我们首先讨论mA修饰在调节DNA修复基因的RNA稳定性和剪接中的作用，以及它在指导DNA修复中的作用。然后，我们讨论mA修饰的RNA与DNA损伤和修复之间的相互作用，突出几个悬而未决的问题。
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