Draeger J, Schloot W, Wirt H
Ophthalmic Paediatr Genet. 1985 Aug;6(1-2):291-5.
By means of an electronic optical esthesiometer corneal sensitivity was examined in 91 volunteers of different age groups. Additionally, the anesthetic duration of the local anesthetic benoxinate was investigated. Corneal sensitivity decreases with advancing age. Comparing male and female subjects, we can suppose that there are age and sex specific differences of corneal sensitivity. There might be additional genetic factors. There are great interindividual differences in the anesthetic duration of benoxinate. It can be assumed that benoxinate is metabolized by pseudocholinesterase. One possible explanation for the great differences in the anesthetic duration of benoxinate can be seen in the genetically determined variants of pseudocholinesterase.
借助电子光学感觉计，对91名不同年龄组的志愿者进行了角膜敏感性检查。此外，还研究了局部麻醉药贝诺酯的麻醉持续时间。角膜敏感性随年龄增长而降低。比较男性和女性受试者，我们可以推测角膜敏感性存在年龄和性别特异性差异。可能还存在其他遗传因素。贝诺酯的麻醉持续时间存在很大的个体差异。可以假定贝诺酯由假性胆碱酯酶代谢。贝诺酯麻醉持续时间差异巨大的一个可能解释在于假性胆碱酯酶的基因决定变体。
