• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Agxt2l介导的滋养细胞甘油磷脂代谢解释了意大利蜜蜂蜂王比中华蜜蜂蜂王产卵量更高的原因。

Agxt2l-mediated glycerophospholipid metabolism in trophocytes explains Apis mellifera queen's higher oviposition over A. cerana.

作者信息

Pan Luxia, Wang Zilong, Zhong Shiqing, Xu Tianyu, Chen Weixuan, Cheng Fuping, Zeng Zhijiang

机构信息

Honeybee Research Institute, Jiangxi Agricultural University, Nanchang, China.

Laboratory Animal Science and Technology Center, Jiangxi University of Chinese Medicine, Nanchang, China.

出版信息

Commun Biol. 2025 Jul 23;8(1):1091. doi: 10.1038/s42003-025-08526-6.

DOI:10.1038/s42003-025-08526-6
PMID:40695985
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12284031/
Abstract

Apis mellifera and Apis cerana are two important honey bee species widely kept and studied. But their queens differ greatly in egg-laying capacity. To determine the mechanisms of this difference, we compare gene expression, chromatin accessibility and spatial localization of differential genes in the ovaries of the two species in virgin queens and laying queens using ATAC-seq, RNA-Seq, homologous gene alignment and spatial transcriptome. The results reconfirm that the egg-laying capability of A. mellifera queens is significantly higher than that of A. cerana queens. The chromatin accessibility and nutrient cells ratio of A. mellifera queens are higher than those of A. cerana queens. Further investigations reveal that agxt2l (LOC408817) is significantly over-expressed in the ovaries of A. mellifera queens compared to A. cerana queens and is crucial for ovary development. Moreover, agxt2l can increase the phospholipid content in ovarian nutrient cells through the glycerophospholipid metabolism pathway to promote embryo formation and is regulated by brc-z1 (LOC552255). These findings suggest that the brc-z1-agxt2l signal pathway causes increased egg-laying in the queens of A. mellifera compared to the queens of A. cerana by accelerating lipid synthesis due to heightened glycerophospholipid metabolism.

摘要

意大利蜜蜂和中华蜜蜂是两种被广泛饲养和研究的重要蜜蜂品种。但它们的蜂王在产卵能力上有很大差异。为了确定这种差异的机制，我们使用ATAC-seq、RNA-Seq、同源基因比对和空间转录组技术，比较了处女蜂王和产卵蜂王卵巢中两种蜜蜂的基因表达、染色质可及性以及差异基因的空间定位。结果再次证实，意大利蜜蜂蜂王的产卵能力显著高于中华蜜蜂蜂王。意大利蜜蜂蜂王的染色质可及性和营养细胞比例高于中华蜜蜂蜂王。进一步研究发现，与中华蜜蜂蜂王相比，agxt2l（LOC408817）在意大利蜜蜂蜂王的卵巢中显著过表达，并且对卵巢发育至关重要。此外，agxt2l可以通过甘油磷脂代谢途径增加卵巢营养细胞中的磷脂含量，以促进胚胎形成，并且受brc-z1（LOC552255）调控。这些发现表明，与中华蜜蜂蜂王相比，brc-z1-agxt2l信号通路通过加速甘油磷脂代谢导致脂质合成增加，从而使意大利蜜蜂蜂王的产卵量增加。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddfe/12284031/884c04deb998/42003_2025_8526_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddfe/12284031/d92f0abc7bc3/42003_2025_8526_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddfe/12284031/0a0c89b2525c/42003_2025_8526_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddfe/12284031/3d00c11a1d86/42003_2025_8526_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddfe/12284031/f6eedb8beae7/42003_2025_8526_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddfe/12284031/acae1d2dcda0/42003_2025_8526_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddfe/12284031/4156fab2db3d/42003_2025_8526_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddfe/12284031/32d8540ad08c/42003_2025_8526_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddfe/12284031/b0ba20592a24/42003_2025_8526_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddfe/12284031/884c04deb998/42003_2025_8526_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddfe/12284031/d92f0abc7bc3/42003_2025_8526_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddfe/12284031/0a0c89b2525c/42003_2025_8526_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddfe/12284031/3d00c11a1d86/42003_2025_8526_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddfe/12284031/f6eedb8beae7/42003_2025_8526_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddfe/12284031/acae1d2dcda0/42003_2025_8526_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddfe/12284031/4156fab2db3d/42003_2025_8526_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddfe/12284031/32d8540ad08c/42003_2025_8526_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddfe/12284031/b0ba20592a24/42003_2025_8526_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddfe/12284031/884c04deb998/42003_2025_8526_Fig9_HTML.jpg

相似文献

1
Agxt2l-mediated glycerophospholipid metabolism in trophocytes explains Apis mellifera queen's higher oviposition over A. cerana.Agxt2l介导的滋养细胞甘油磷脂代谢解释了意大利蜜蜂蜂王比中华蜜蜂蜂王产卵量更高的原因。
Commun Biol. 2025 Jul 23;8(1):1091. doi: 10.1038/s42003-025-08526-6.
2
Comparative transcriptome analysis reveals various host responses to sacbrood virus infection in Apis cerana and Apis mellifera.比较转录组分析揭示了中华蜜蜂和西方蜜蜂对囊状幼虫病毒感染的多种宿主反应。
BMC Genomics. 2025 Jul 1;26(1):592. doi: 10.1186/s12864-025-11779-4.
3
Dissection of genetic basis underlying heat stress response of Apis cerana.中华蜜蜂热应激反应潜在遗传基础的剖析。
BMC Genomics. 2025 May 20;26(1):512. doi: 10.1186/s12864-025-11714-7.
4
Are you my mother? When host genetics and gut microbiota tell different phylogenetic stories in the Africanized honey bee hybrid ( × sspp.).你是我的母亲吗？当宿主遗传学和肠道微生物群在非洲化蜜蜂杂交种（× sspp.）中讲述不同的系统发育故事时。
Microbiol Spectr. 2025 Jul;13(7):e0247524. doi: 10.1128/spectrum.02475-24. Epub 2025 May 28.
5
Breakthrough research on reinsemination of bee queens with imaging of reproductive system elements.通过对生殖系统元件进行成像，实现蜂王再授精的突破性研究。
Sci Rep. 2025 Jul 1;15(1):20810. doi: 10.1038/s41598-025-03278-z.
6
Evolutionary trends in CRISPR-Cas systems.CRISPR-Cas系统的进化趋势。
mSystems. 2025 Jun 18:e0016625. doi: 10.1128/msystems.00166-25.
7
A miR-JL-5 inhibitor modulates the proliferation of e in .一种miR-JL-5抑制剂调节……中e的增殖。（原文中“e in.”表述不完整，可能影响准确理解）
Front Insect Sci. 2025 Jun 4;5:1583941. doi: 10.3389/finsc.2025.1583941. eCollection 2025.
8
A systematic review of honey bee (Apis mellifera, Linnaeus, 1758) infections and available treatment options.蜜蜂（Apis mellifera，Linnaeus，1758）感染及现有治疗方法的系统评价。
Vet Med Sci. 2023 Jul;9(4):1848-1860. doi: 10.1002/vms3.1194. Epub 2023 Jun 19.
9
Queen honey bee (Apis mellifera) survival and colony performance after overwintering mated queens indoors.室内越冬交尾蜂王后的蜂王（意大利蜜蜂）存活情况及蜂群性能
J Econ Entomol. 2025 Aug 29;118(4):1512-1518. doi: 10.1093/jee/toaf022.
10
Probiotic effects on ectoparasitic mite infestations in honey bees () are modulated by environmental conditions and route of administration.益生菌对蜜蜂体外寄生螨侵扰的影响受环境条件和给药途径的调节。
Microbiol Spectr. 2025 Jul;13(7):e0249824. doi: 10.1128/spectrum.02498-24. Epub 2025 May 22.

本文引用的文献

1
CRISPR/Cas9-induced Mutation of Sex Peptide Receptor Gene Bdspr Affects Ovary, Egg Laying, and Female Fecundity in Bactrocera dorsalis (Hendel) (Diptera: Tephritidae).CRISPR/Cas9 诱导的性肽受体基因 Bdspr 突变影响 Bactrocera dorsalis (Hendel) (双翅目：瘿蚊科)的卵巢、产卵和雌性生殖力。
J Insect Sci. 2023 Jan 1;23(1). doi: 10.1093/jisesa/ieac078.
2
The molecular basis of socially induced egg-size plasticity in honey bees.社会性诱导蜜蜂卵大小可塑性的分子基础。
Elife. 2022 Nov 8;11:e80499. doi: 10.7554/eLife.80499.
3
Effects and Mechanism of Different Phospholipid Diets on Ovary Development in Female Broodstock Pacific White Shrimp, .
不同磷脂日粮对雌性亲虾凡纳滨对虾卵巢发育的影响及机制
Front Nutr. 2022 Feb 18;9:830934. doi: 10.3389/fnut.2022.830934. eCollection 2022.
4
Bee Products: A Representation of Biodiversity, Sustainability, and Health.蜂产品：生物多样性、可持续性与健康的体现
Life (Basel). 2021 Sep 15;11(9):970. doi: 10.3390/life11090970.
5
Factors Influencing the Reproductive Ability of Male Bees: Current Knowledge and Further Directions.影响雄蜂繁殖能力的因素：当前认知与未来方向
Insects. 2021 Jun 7;12(6):529. doi: 10.3390/insects12060529.
6
Integrated analysis of multimodal single-cell data.多模态单细胞数据的综合分析。
Cell. 2021 Jun 24;184(13):3573-3587.e29. doi: 10.1016/j.cell.2021.04.048. Epub 2021 May 31.
7
Health Promoting Properties of Bee Royal Jelly: Food of the Queens.蜂王浆的保健功效：女王的食物。
Nutrients. 2021 Feb 7;13(2):543. doi: 10.3390/nu13020543.
8
RNA mA Modification Functions in Larval Development and Caste Differentiation in Honeybee (Apis mellifera).RNA mA 修饰在幼虫发育和蜜蜂（Apis mellifera）级型分化中的功能。
Cell Rep. 2021 Jan 5;34(1):108580. doi: 10.1016/j.celrep.2020.108580.
9
Global Patterns and Drivers of Bee Distribution.全球蜜蜂分布格局及其驱动因素。
Curr Biol. 2021 Feb 8;31(3):451-458.e4. doi: 10.1016/j.cub.2020.10.053. Epub 2020 Nov 19.
10
Transgenerational accumulation of methylome changes discovered in commercially reared honey bee (Apis mellifera) queens.商业养殖蜂王（Apis mellifera）中发现的甲基组变化的跨代积累。
Insect Biochem Mol Biol. 2020 Dec;127:103476. doi: 10.1016/j.ibmb.2020.103476. Epub 2020 Oct 11.