Park Junhee, Han Kyungdo, Kim Bongseong, Lee Kyungho, Jang Hye Ryoun, Yoon Je Moon, Lim Dong Hui, Shin Dong Wook
Center for Health Promotion, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, 06351, Republic of Korea.
Department of Statistics and Actuarial Science, Soongsil University, 369 Sangdo-ro, Dongjak-gu Seoul, Seoul, 06978, Republic of Korea.
Sci Rep. 2025 Jul 22;15(1):26595. doi: 10.1038/s41598-025-12297-9.
The association between chronic kidney disease (CKD) and the risk of age-related macular degeneration (AMD) is unclear. Our study aimed to evaluate this relationship considering the potential impact of proteinuria. This retrospective cohort study used a large representative population sample from the Korean National Health Insurance Service database (2009-2019) of individuals who participated in a national health screening program in 2009. CKD was determined by estimated glomerular filtration rate (eGFR). Proteinuria was assessed using dipstick urinalysis. AMD was identified according to International Classification Disease, Tenth Revision, codes in claims data. The Cox regression hazards model was used to estimate the association between CKD and risk of AMD. Among 4,005,946 participants, 400,189 (10.0%) had CKD. There was no significant association between CKD and AMD, but a positive relationship was identified between proteinuria and AMD. In stratification analysis with age and sex, the risk of AMD was more evident in younger (< 65 years) than older individuals (P-interaction < 0.001) and in men than women (P-interaction < 0.001). A positive association between proteinuria and AMD risk was observed and was prominent in younger males.
慢性肾脏病（CKD）与年龄相关性黄斑变性（AMD）风险之间的关联尚不清楚。我们的研究旨在考虑蛋白尿的潜在影响来评估这种关系。这项回顾性队列研究使用了来自韩国国民健康保险服务数据库（2009 - 2019年）的大量具有代表性的人群样本，这些个体参加了2009年的全国健康筛查项目。CKD通过估计肾小球滤过率（eGFR）来确定。蛋白尿通过尿试纸条分析进行评估。AMD根据国际疾病分类第十版编码在理赔数据中进行识别。采用Cox回归风险模型来估计CKD与AMD风险之间的关联。在4,005,946名参与者中，400,189名（10.0%）患有CKD。CKD与AMD之间无显著关联，但蛋白尿与AMD之间存在正相关关系。在按年龄和性别进行的分层分析中，AMD风险在较年轻（<65岁）个体中比在较年长个体中更明显（P交互作用<0.001），在男性中比在女性中更明显（P交互作用<0.001）。观察到蛋白尿与AMD风险之间存在正相关，且在较年轻男性中尤为突出。
