Lv Yudie, Yang Yang, Niu Jiaxin, Sun Xu, Zhang Han, Kong Xiangdong
Institute of Smart Biomedical Materials, School of Materials Science and Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, China.
Zhejiang-Mauritius Joint Research Center for Biomaterials and Tissue Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, China.
J Mater Chem B. 2025 Aug 13;13(32):9982-9992. doi: 10.1039/d5tb00960j.
Oxidative stress is closely linked to androgenetic alopecia (AGA). However, research on antioxidants specifically targeting hair follicle tissue has been limited. The utilization of nanomaterials that possess superior reactive oxygen species (ROS)-scavenging capabilities and biocompatibility is a promising approach for the treatment of AGA. The microneedle-mediated transdermal delivery system can overcome the limitations of the stratum corneum and effectively deliver functional nanomaterials to the vicinity of hair follicles. In this study, we report a degradable microneedle patch loaded with a ROS-scavenging CuO nanozyme (CuO-MNs) for targeted treatment of AGA. Tiny CuO nanozymes were synthesized using a robust and eco-friendly method, demonstrating an effective ROS-scavenging ability at both and cellular levels. With the penetration and dissolution of sodium hyaluronate microneedles, CuO can be rapidly released and effectively reach the area around the hair follicle, enabling targeted removal of ROS. In the AGA model, CuO-MNs effectively alleviate oxidative stress, restore the hair follicle microenvironment, and stimulate the transition of hair follicles from the telogen to the anagen. These combined effects significantly enhance hair regeneration and exhibit therapeutic efficacy comparable to the clinical drug minoxidil, suggesting the safety and translational potential of this strategy for AGA treatment.
氧化应激与雄激素性脱发（AGA）密切相关。然而，针对毛囊组织的抗氧化剂研究一直有限。利用具有卓越活性氧（ROS）清除能力和生物相容性的纳米材料是治疗AGA的一种有前景的方法。微针介导的透皮给药系统可以克服角质层的限制，并有效地将功能性纳米材料递送至毛囊附近。在本研究中，我们报道了一种负载ROS清除型氧化铜纳米酶（CuO-MNs）的可降解微针贴片，用于靶向治疗AGA。采用一种稳健且环保的方法合成了微小的CuO纳米酶，其在体外和细胞水平均表现出有效的ROS清除能力。随着透明质酸钠微针的穿透和溶解，CuO能够迅速释放并有效到达毛囊周围区域，实现对ROS的靶向清除。在AGA模型中，CuO-MNs有效减轻氧化应激，恢复毛囊微环境，并刺激毛囊从休止期向生长期转变。这些综合作用显著促进毛发生长，并且表现出与临床药物米诺地尔相当的治疗效果，表明该策略用于AGA治疗的安全性和转化潜力。
