Xu Man, Yang Fanglei, Chen Huan, Jiang Feiyun
Department of Gynecology, The Second People's Hospital of Wuhu City, Wuhu, Anhui 241000, P.R. China.
Oncol Lett. 2025 Jul 14;30(3):442. doi: 10.3892/ol.2025.15188. eCollection 2025 Sep.
Cervical cancer is one of the most common malignant tumors among women worldwide. Its primary etiology is closely associated with human papillomavirus infection, which poses a serious threat to the health of women. N6-methyladenosine (m6A) modifications notably affect the biological characteristics of tumor cells, such as their proliferation, metastasis and chemoresistance, by regulating the stability, translation and degradation of RNA. It also serves an important regulatory role in the pathogenesis of cervical cancer. The present review details the mechanisms underlying m6A modification in cervical cancer and analyzes its impact on tumor progression. Moreover, it explores the potential clinical applications of m6A modification as a biomarker and therapeutic target to provide new insights and evidence regarding the early diagnosis and individualized treatment of patients with cervical cancer.
宫颈癌是全球女性中最常见的恶性肿瘤之一。其主要病因与人类乳头瘤病毒感染密切相关，对女性健康构成严重威胁。N6-甲基腺嘌呤（m6A）修饰通过调节RNA的稳定性、翻译和降解，显著影响肿瘤细胞的生物学特性，如增殖、转移和化疗耐药性。它在宫颈癌的发病机制中也起着重要的调节作用。本综述详细阐述了宫颈癌中m6A修饰的潜在机制，并分析了其对肿瘤进展的影响。此外，还探讨了m6A修饰作为生物标志物和治疗靶点的潜在临床应用，为宫颈癌患者的早期诊断和个体化治疗提供新的见解和证据。
