Boris Jeffrey R, Shadiack Edward C, McCormick Elizabeth M, MacMullen Laura E, George-Sankoh Ibrahim, Fitzgerald Frances, Falk Marni
Jeffrey R. Boris, Moylan, Pennsylvania, USA.
War Related Illness and Injury Study Center, VA New Jersey Healthcare System, East Orange, New Jersey, USA.
Obstet Gynecol Int. 2025 Jul 15;2025:8872884. doi: 10.1155/ogi/8872884. eCollection 2025.
Postural orthostatic tachycardia syndrome (POTS) affects up to 3 million people in the United States. Although 78%-83% of POTS patients are female, gynecologic comorbidity has not been well-studied. We created an online questionnaire to assess outcomes in female patients with POTS formerly followed at a single-center pediatric POTS program. Cross-sectional study. Single-center pediatric POTS program. All female patients ≤ 18 years at diagnosis. We developed and distributed The Long-Term POTS Outcomes Survey with questions about diagnosis, therapy, education, employment, social impact, quality of life (QoL), and gynecologic symptoms and management. Gynecologic symptoms and QoL. Regular menstrual cycles were seen in 81/167 participants (49.1%). POTS symptoms worsened prior to and during menses in 118/167 subjects (72.4%); hormonal contraceptive therapy helped to control symptoms in 52/110 subjects (50%). Menorrhagia, polycystic ovary syndrome, and endometriosis were not reported in higher numbers compared to the general population. Menstrual flow disorders are not more prevalent in younger females with POTS. Symptoms often worsen perimenstrually, and hormone therapy can help to reduce symptom severity. Further research is needed to better define optimal hormone therapy in suppressing perimenstrual symptoms.
体位性直立性心动过速综合征（POTS）在美国影响着多达300万人。尽管78%-83%的POTS患者为女性，但妇科合并症尚未得到充分研究。我们创建了一份在线问卷，以评估曾在单中心儿科POTS项目接受治疗的女性POTS患者的预后情况。横断面研究。单中心儿科POTS项目。所有诊断时年龄≤18岁的女性患者。我们编制并发放了“POTS长期预后调查问卷”，内容涉及诊断、治疗、教育、就业、社会影响、生活质量（QoL）以及妇科症状和管理等方面。妇科症状与生活质量。167名参与者中有81名（49.1%）月经周期规律。167名受试者中有118名（72.4%）在月经前和月经期间POTS症状加重；110名受试者中有52名（50%）通过激素避孕疗法症状得到控制。与普通人群相比，月经过多、多囊卵巢综合征和子宫内膜异位症的报告数量并未增加。月经流量紊乱在年轻女性POTS患者中并不更常见。症状常在围经期加重，激素疗法有助于减轻症状严重程度。需要进一步研究以更好地确定抑制围经期症状的最佳激素疗法。
