Hu Jilei, Lang Hongmei, Fan Die, Wen Ting, Shi Jiaojiao, Xiao Chunxiu, Li Yunming, Kang Chao, Shi Peijie, Shen Lirong, Lin Ning
Department of Clinical Nutrition, The General Hospital of Western Theater Command, Chengdu, China.
Department of General Medicine, Chengdu Second People's Hospital, Chengdu, China.
Front Nutr. 2025 Jul 8;12:1572376. doi: 10.3389/fnut.2025.1572376. eCollection 2025.
Previous evidence showed that curcumin enhanced the oxygen supply efficiency of hemoglobin and alleviated acute plateau hypoxia injury in animal models. However, its efficacy on human beings is not yet verified. This study aimed to assess the effects of curcumin supplementation on hypoxia injury and gut microbiota in the male Han population.
In this 7-week single-blinded randomized trial, 102 male Han population urgently entered the 3,000 meters altitude from the plain and received 812 mg curcumin or placebo per day for 1 week on the plain and 6 weeks on the plateau. Biochemical parameters were assessed and physical examination was carried out at the baseline (T0), and the end of the 1st (T) and 7th week (T) of intervention. The score of acute mountain sickness (AMS) was evaluated in the 2nd week after entering the plateau (T) and T. Intestine microbial composition was analyzed by metagenomic sequencing.
After a 1-week intervention on the plain, curcumin significantly increased red blood cells (RBC), hematocrit (HCT), and hemoglobin in treatment group as compared to placebo group ( < 0.05). However, curcumin significantly reduced the levels of HCT and hemoglobin compared to that in the placebo group after the 6-week intervention on the plateau ( < 0.05). Furthermore, the score of AMS in the curcumin group were lower than those in the placebo group at T, although with no significant difference. Gut microbiota analysis indicated that curcumin significantly increased the abundance of butyrate-producing bacteria , and while decreasing the abundance of and at high-altitude environments. In addition, a higher relative abundance of was observed in the curcumin group on the plateau.
Curcumin exhibited different regulation of hemoglobin in low- and high-altitude environments. On the plain, curcumin supplementation elevated the RBC and hemoglobin, which is favorable for reducing the incidence of AMS at the early stage of entering the plateau. On the plateau, curcumin suppressed excessive increase of HCT and hemoglobin by modulating the abundance of butyrate-producing bacteria to avoid the occurrence of high-altitude polycythemia.
https://www.chictr.org.cn/, identifier: ChiCTR220005965.
先前的证据表明，姜黄素可提高血红蛋白的氧供应效率，并减轻动物模型中的急性高原低氧损伤。然而，其对人类的疗效尚未得到验证。本研究旨在评估补充姜黄素对汉族男性人群低氧损伤和肠道微生物群的影响。
在这项为期7周的单盲随机试验中，102名汉族男性从平原紧急进入海拔3000米处，在平原上每天接受812毫克姜黄素或安慰剂治疗1周，在高原上治疗6周。在基线（T0）、干预第1周（T1）和第7周（T7）结束时评估生化参数并进行体格检查。在进入高原后第2周（T2）和T7评估急性高山病（AMS）评分。通过宏基因组测序分析肠道微生物组成。
在平原上进行1周干预后，与安慰剂组相比，姜黄素显著增加了治疗组的红细胞（RBC）、血细胞比容（HCT）和血红蛋白水平（P<0.05）。然而，在高原上进行6周干预后，与安慰剂组相比，姜黄素显著降低了HCT和血红蛋白水平（P<0.05）。此外，在T7时，姜黄素组的AMS评分低于安慰剂组，尽管差异不显著。肠道微生物群分析表明，在高海拔环境中，姜黄素显著增加了产丁酸菌的丰度，同时降低了的丰度。此外，在高原上，姜黄素组中观察到相对丰度较高。
姜黄素在低海拔和高海拔环境中对血红蛋白表现出不同的调节作用。在平原上，补充姜黄素可提高RBC和血红蛋白水平，有利于降低进入高原早期AMS的发生率。在高原上，姜黄素通过调节产丁酸菌的丰度抑制HCT和血红蛋白的过度增加，以避免高原红细胞增多症的发生。
