姜黄素对血压的影响：一项系统评价与剂量反应荟萃分析
Effects of curcumin on blood pressure: A systematic review and dose-response meta-analysis.
作者信息
Karimi Arash, Moini Jazani Arezoo, Darzi Melika, Doost Azgomi Ramin Nasimi, Vajdi Mahdi
机构信息
Traditional Medicine and Hydrotherapy Research Center, Ardabil University of Medical Sciences, Ardabil, Iran; Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tabriz, University of Medical Sciences, Tabriz, Iran.
Traditional Medicine and Hydrotherapy Research Center, Ardabil University of Medical Sciences, Ardabil, Iran.
出版信息
Nutr Metab Cardiovasc Dis. 2023 Nov;33(11):2089-2101. doi: 10.1016/j.numecd.2023.07.003. Epub 2023 Jul 8.
AIMS
This systematic review and dose-response meta-analysis were conducted to summarize data from available clinical trials on the effects of curcumin supplementation on systolic BP (SBP) and diastolic BP (DBP).
DATA SYNTHESIS
Using related keywords, multiple databases, including the Web of Sciences, Scopus, Embase, PubMed, Cochrane Library, and Google Scholar, were searched until November 2022. We chose the studies that examined the effects of curcumin on systolic blood pressure (SBP) and diastolic blood pressure (DBP). Seventeen eligible studies with a total sample size of 1377 participants were included in the meta-analysis. The findings of the meta-analysis did not indicate any significant effect of curcumin on SBP (WMD = -0.06 mmHg, 95% CI: -0.62, 0.50, p = 0.85; I = 44.2%) and DBP (WMD = -0.18 mmHg, 95% CI: -1.17, 0.82, p = 0.62; I = 77.2%). Moreover, in our dose-response analysis, we found that the dose and duration of curcumin supplementation were non-significantly associated with the reduction of SBP and DBP. However, subgroup analysis revealed a significant reduction only in DBP levels (WMD: -0.76 mmHg, 95% CI: -1.46,-0.05; P = 0.03) but not in SBP in studies with ≥12-week supplementation. Also, a significant reduction in SBP (WMD: -1.55 mmHg, 95% CI: -2.85, -0.25; P = 0.01) and DBP (WMD: -1.73 mmHg, 95% CI: 2.67, -0.79; P < 0.01) was noticed by curcumin supplementation in studies performed on women.
CONCLUSIONS
The current study suggests that consuming curcumin may improve DBP when administered for long durations ≥12 weeks. However, more trials are required to confirm these findings.
目的
进行本系统评价和剂量反应荟萃分析，以总结现有关于补充姜黄素对收缩压（SBP）和舒张压（DBP）影响的临床试验数据。
数据综合
使用相关关键词，检索了多个数据库，包括科学网、Scopus、Embase、PubMed、Cochrane图书馆和谷歌学术，检索截至2022年11月。我们选择了研究姜黄素对收缩压（SBP）和舒张压（DBP）影响的研究。荟萃分析纳入了17项符合条件的研究，总样本量为1377名参与者。荟萃分析结果未表明姜黄素对SBP（加权均数差[WMD]=-0.06mmHg，95%置信区间：-0.62，0.50，p=0.85；I²=44.2%）和DBP（WMD=-0.18mmHg，95%置信区间：-1.17，0.82，p=0.62；I²=77.2%）有任何显著影响。此外，在我们的剂量反应分析中，我们发现补充姜黄素的剂量和持续时间与SBP和DBP的降低无显著关联。然而，亚组分析显示，在补充时间≥12周的研究中，仅DBP水平显著降低（WMD：-0.76mmHg，95%置信区间：-1.46，-0.05；P=0.03），而SBP未降低。同样，在针对女性进行的研究中，补充姜黄素可使SBP（WMD：-1.55mmHg，95%置信区间：-2.85，-0.25；P=0.01）和DBP（WMD：-1.73mmHg，95%置信区间：-2.67，-0.79；P<0.01）显著降低。
结论
当前研究表明，长期（≥12周）服用姜黄素可能会改善DBP。然而，需要更多试验来证实这些发现。
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