Ding Na, Zhao Jianru, Tian Feng, Li Hui
Department of Gastroenterology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.
Front Med (Lausanne). 2025 Jul 8;12:1587226. doi: 10.3389/fmed.2025.1587226. eCollection 2025.
This case report and literature review present a 52-year-old male with a sigmoid eosinophilic abscess (EA) complicated by eosinophilic vasculitis (EoV), resulting in thrombosis and intestinal perforation. The patient presented with acute abdominal pain and melena. Laboratory tests revealed marked eosinophilia, elevated D-dimer levels, and a white blood cell count consistent with systemic inflammation. Contrast-enhanced computed tomography (CECT) identified extensive vascular thrombosis and bowel wall compromise, necessitating surgical intervention. Histopathological examination confirmed the diagnosis of EA with associated eosinophilic infiltration in the intestinal wall. This case highlights the diagnostic and therapeutic challenges of eosinophilic disorders, particularly the need for awareness of their potential complications. It also emphasizes the importance of timely intervention in managing such rare conditions. Through a review of the relevant literature, we further discuss the characteristics, differential diagnosis, and management strategies for EA and EoV.
本病例报告及文献综述介绍了一名52岁男性，患有乙状结肠嗜酸性脓肿（EA）并伴有嗜酸性血管炎（EoV），导致血栓形成和肠穿孔。患者表现为急性腹痛和黑便。实验室检查显示明显的嗜酸性粒细胞增多、D-二聚体水平升高以及与全身炎症相符的白细胞计数。增强计算机断层扫描（CECT）发现广泛的血管血栓形成和肠壁受损，需要进行手术干预。组织病理学检查证实为EA，并伴有肠壁嗜酸性浸润。本病例突出了嗜酸性疾病的诊断和治疗挑战，特别是需要认识到其潜在并发症。它还强调了及时干预管理此类罕见疾病的重要性。通过对相关文献的回顾，我们进一步讨论了EA和EoV的特征、鉴别诊断及管理策略。
