de Fontes-Junior Antônio Alves, de Sousa Cesar Augustus Zocoler, de Oliveira Leandro Barbosa, Sierra Ana Paula Renno, Cury-Boaventura Maria Fernanda
Interdisciplinary Post-Graduate Program in Health Sciences, Cruzeiro do Sul University, São Paulo, Brazil.
School of Physical Education and Sport, University of São Paulo, São Paulo, Brazil.
Front Physiol. 2025 Jul 8;16:1546370. doi: 10.3389/fphys.2025.1546370. eCollection 2025.
Decorin is secreted from myotubes in response to exercise and plays a vital role in repairing and regenerate skeletal and cardiac muscle. The role of decorin levels in cardiometabolic function after endurance exercise was investigated.
Fifty-six male amateur runners, aged 30 to 55 years, participated in this study. Plasma decorin levels were determined and cardiopulmonary exercise test (CPET) was performed using a breath-by-breath system before and after the marathon.
Correlations between decorin levels and CPET parameters were assessed using Spearman's rank correlation test. Runners were categorized into percentiles based on decorin concentrations, and group differences were analyzed using the Kruskal-Wallis test followed by Dunn's post hoc multiple comparisons.We observed impairments in peak VO and in the Oxygen Uptake Efficiency Slope (OUES) following the race. Plasma decorin levels increased approximately two-fold immediately after the race. Post-race decorin concentrations were positively correlated with maximum speed (km/h), VO (mL/kg/min), VE/VCO, VE/VCO slope, OUES, and the rate of change in VE/VCO and VE/VCO slope. Runners with plasma decorin levels below the 25th percentile exhibited significantly lower OUES, while those above the 75th percentile demonstrated higher maximum speed, VE/VCO, rate of change in VE/VCO slope, and VCO compared to individuals in the lowest quartile.
Overall, decorin levels were associated with several CPET parameters, suggesting that runners with varying decorin concentrations may exhibit distinct respiratory and/or metabolic profiles. The potential influence of an elevated VE/VCO slope on cardiometabolic responses in runners with higher decorin levels warrants further investigation.
核心蛋白聚糖是肌管在运动刺激下分泌的产物，在骨骼肌和心肌的修复与再生中发挥着至关重要的作用。本研究旨在探究耐力运动后核心蛋白聚糖水平在心脏代谢功能中的作用。
56名年龄在30至55岁之间的男性业余跑步者参与了本研究。在马拉松比赛前后，使用逐次呼吸系统测定血浆核心蛋白聚糖水平，并进行心肺运动试验（CPET）。
使用Spearman等级相关检验评估核心蛋白聚糖水平与CPET参数之间的相关性。根据核心蛋白聚糖浓度将跑步者分为百分位数组，并使用Kruskal-Wallis检验分析组间差异，随后进行Dunn事后多重比较。我们观察到比赛后峰值摄氧量（VO）和摄氧效率斜率（OUES）出现了下降。比赛后血浆核心蛋白聚糖水平立即升高了约两倍。赛后核心蛋白聚糖浓度与最高速度（km/h）、VO（mL/kg/min）、VE/VCO、VE/VCO斜率、OUES以及VE/VCO和VE/VCO斜率的变化率呈正相关。血浆核心蛋白聚糖水平低于第25百分位数的跑步者OUES显著降低，而高于第75百分位数的跑步者与最低四分位数组相比，最高速度、VE/VCO、VE/VCO斜率变化率和VCO更高。
总体而言，核心蛋白聚糖水平与多个CPET参数相关，这表明不同核心蛋白聚糖浓度的跑步者可能表现出不同的呼吸和/或代谢特征。较高的VE/VCO斜率对核心蛋白聚糖水平较高的跑步者心脏代谢反应的潜在影响值得进一步研究。
