Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, 60-355 Poznań, Poland.
Department of Cardiology-Intensive Therapy, Poznan University of Medical Sciences, 60-355 Poznań, Poland.
Int J Environ Res Public Health. 2021 Jan 31;18(3):1261. doi: 10.3390/ijerph18031261.
Different forms of physical activity-endurance, resistance or dynamic power-stimulate cytokine release from various tissues to the bloodstream. Receptors for exercise-induced cytokines are present in muscle tissue, adipose tissue, liver, brain, bones, cardiovascular system, immune system, pancreas, and skin. They have autocrine, paracrine and endocrine activities. Many of them regulate the myocyte growth and differentiation necessary for muscle hypertrophy and myogenesis. They also modify energy homeostasis, lipid, carbohydrate, and protein metabolism, regulate inflammation and exchange information (crosstalk) between remote organs. So far, interleukin 6 and irisin have been the best studied exercise-induced cytokines. However, many more can be grouped into myokines, hepatokines and adipomyokines. This review focuses on the less known exercise-induced cytokines such as myostatin, follistatin, decorin, brain-derived neurotrophic factor, fibroblast growth factor 21 and interleukin 15, and their relation to various forms of exercise, i.e., acute vs. chronic, regular training in healthy people.
不同形式的身体活动——耐力、抗阻或动力——刺激来自各种组织的细胞因子释放到血液中。运动诱导的细胞因子受体存在于肌肉组织、脂肪组织、肝脏、大脑、骨骼、心血管系统、免疫系统、胰腺和皮肤中。它们具有自分泌、旁分泌和内分泌活性。其中许多调节肌细胞生长和分化，这是肌肉肥大和肌发生所必需的。它们还调节能量稳态、脂质、碳水化合物和蛋白质代谢，调节炎症，并在远程器官之间交换信息（串扰）。到目前为止，白细胞介素 6 和鸢尾素是研究最多的运动诱导细胞因子。然而，还有更多的细胞因子可以被归类为肌因子、肝细胞因子和脂肪肌细胞因子。这篇综述重点介绍了一些鲜为人知的运动诱导细胞因子，如肌肉生长抑制素、卵泡抑素、核心蛋白聚糖、脑源性神经营养因子、成纤维细胞生长因子 21 和白细胞介素 15，以及它们与各种形式的运动的关系，如急性与慢性、健康人群的规律训练。
Zotero 插件