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用于治疗性敷料的大麻衍生醋酸纤维素电纺膜：提取、表征及原型开发

Cannabis-derived cellulose acetate electrospun membranes for therapeutic dressings: extraction, characterization, and prototype development.

作者信息

Lara Adriana, Cely Erika, Gómez-Pachón Edwin, Rubiano-Navarrete Andres, López Alex, Antosik Adrian Krzysztof, Vendrell Xavier, Serafin Jarosław

机构信息

Grupo de investigación en diseño, Innovación y Asistencia Técnica para Materiales Avanzados-DITMAV, Escuela de Diseño Industrial, Universidad Pedagógica y Tecnológica de Colombia-UPTC, Duitama, Colombia.

Grupo de Investigación en Bioeconomía y Sostenibilidad Agroalimentaria, Escuela de Administración de Empresas Agropecuarias, Facultad Seccional Duitama, Universidad Pedagógica y Tecnológica de Colombia, Duitama, Colombia.

出版信息

Front Chem. 2025 Jul 8;13:1624736. doi: 10.3389/fchem.2025.1624736. eCollection 2025.

DOI:10.3389/fchem.2025.1624736
PMID:40698058
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12279836/
Abstract

This work reports the development of electrospun cellulose acetate (CA) membranes derived from biomass for potential use in therapeutic dressings. Cellulose was extracted from cannabis stalks using alkaline pulping and bleaching, followed by homogeneous acetylation to obtain CA with controlled substitution. CA solutions (13%-25%) were electrospun under varying parameters, and the 17% formulation yielded the most homogeneous, bead-free nanofibers. The resulting membranes were characterized using FTIR, XRD, Raman spectroscopy, UV-Vis spectrophotometry, and SEM. FTIR and Raman confirmed acetylation through characteristic ester and methyl group vibrations. XRD revealed reduced crystallinity in CA compared to native cellulose. SEM analysis showed uniform fiber networks with diameters between 500 and 800 nm. A bilayer dressing prototype was fabricated by integrating the electrospun membrane with a medical-grade silicone adhesive. Adhesion performance was evaluated on synthetic skin using a FINAT-standardized 180° peel test. The membranes demonstrated adequate mechanical cohesion and conformability, supporting their application as sustainable, plant-based biomedical patches.

摘要

这项工作报道了由生物质衍生的电纺醋酸纤维素（CA）膜的开发，其具有用于治疗性敷料的潜在用途。使用碱性制浆和漂白从大麻茎中提取纤维素，然后进行均相乙酰化以获得具有可控取代度的CA。在不同参数下对13%-25%的CA溶液进行电纺，17%的配方产生了最均匀、无珠的纳米纤维。使用傅里叶变换红外光谱（FTIR）、X射线衍射（XRD）、拉曼光谱、紫外可见分光光度法和扫描电子显微镜（SEM）对所得膜进行表征。FTIR和拉曼光谱通过特征性的酯基和甲基振动证实了乙酰化。XRD显示与天然纤维素相比，CA的结晶度降低。SEM分析显示直径在500至800纳米之间的均匀纤维网络。通过将电纺膜与医用级有机硅粘合剂结合，制备了双层敷料原型。使用FINAT标准化的180°剥离试验在合成皮肤上评估粘附性能。这些膜表现出足够的机械内聚力和顺应性，支持它们作为可持续的、基于植物的生物医学贴片的应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3564/12279836/5cfefc28df47/fchem-13-1624736-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3564/12279836/843a865018bd/fchem-13-1624736-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3564/12279836/73375ec7a2a6/fchem-13-1624736-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3564/12279836/c50c5a39c005/fchem-13-1624736-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3564/12279836/81c1eebd609f/fchem-13-1624736-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3564/12279836/bd8b2acb7c47/fchem-13-1624736-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3564/12279836/b3e8404e9550/fchem-13-1624736-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3564/12279836/5914e8c25492/fchem-13-1624736-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3564/12279836/e09c36c72c20/fchem-13-1624736-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3564/12279836/5cfefc28df47/fchem-13-1624736-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3564/12279836/843a865018bd/fchem-13-1624736-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3564/12279836/73375ec7a2a6/fchem-13-1624736-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3564/12279836/c50c5a39c005/fchem-13-1624736-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3564/12279836/81c1eebd609f/fchem-13-1624736-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3564/12279836/bd8b2acb7c47/fchem-13-1624736-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3564/12279836/b3e8404e9550/fchem-13-1624736-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3564/12279836/5914e8c25492/fchem-13-1624736-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3564/12279836/e09c36c72c20/fchem-13-1624736-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3564/12279836/5cfefc28df47/fchem-13-1624736-g009.jpg

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