Teodor Cerbulescu, Ramona Barac Ileana, Ovidiu Boruga, Casiana Sălăvăţ Mădălina, Laurenţiu Leuştean, Daciana Duncă Ştefan, Andrei Calancea, Diana Barac Andreea
"Victor Babeş" University of Medicine and Pharmacy, Timişoara, Romania.
"Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
Rom J Ophthalmol. 2025 Apr-Jun;69(2):208-211. doi: 10.22336/rjo.2025.33.
Matrix metalloproteinases are crucial proteolytic enzymes involved in the degradation and remodeling of the extracellular matrix within the ocular structures. Their expression and activity significantly influence aqueous humor dynamics and intraocular pressure in patients with glaucoma. Elevated intraocular pressure, a significant risk factor for glaucoma, is often associated with disturbed aqueous humor outflow. This review summarizes current findings on the role of matrix metalloproteinases in modulating aqueous humor and their potential as therapeutic targets in the treatment of glaucoma.
基质金属蛋白酶是关键的蛋白水解酶，参与眼部结构中细胞外基质的降解和重塑。它们的表达和活性对青光眼患者的房水动力学和眼压有显著影响。眼压升高是青光眼的一个重要危险因素，常与房水流出受阻有关。本综述总结了关于基质金属蛋白酶在调节房水中的作用及其作为青光眼治疗靶点的潜力的当前研究结果。
