Varghese Nezy, Rajesh R, Krishnan Darsana, Vasu Sreelakshmi
Pediatric and Preventive Dentistry, Indira Gandhi Institute of Dental Sciences, Nellikuzhi, IND.
Cureus. 2025 Jun 22;17(6):e86519. doi: 10.7759/cureus.86519. eCollection 2025 Jun.
Gingival enlargement occurs secondary to the usage of anti-epileptics. The severity of overgrowth varies among different classes of drugs, with phenytoin having the highest incidence of reported cases, whereas cases associated with sodium valproate are minimal. Factors like drug dose, genetic factors, plaque, gingival inflammation, and periodontal health influence the degree of overgrowth. This case report presents one of the first surgically managed cases of generalized gingival enlargement in a pediatric patient due to chronic usage of sodium valproate.
牙龈增生继发于抗癫痫药物的使用。不同种类药物导致的增生严重程度各异,苯妥英钠报告病例的发生率最高,而丙戊酸钠相关病例极少。药物剂量、遗传因素、菌斑、牙龈炎症和牙周健康等因素会影响增生程度。本病例报告展示了首例因长期使用丙戊酸钠导致的小儿全身性牙龈增生并接受手术治疗的病例。