• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

丙戊酸钠致小儿牙龈增生：1例手术干预病例报告

Sodium Valproate-Induced Gingival Enlargement in a Pediatric Patient: A Case Report With Surgical Intervention.

作者信息

Varghese Nezy, Rajesh R, Krishnan Darsana, Vasu Sreelakshmi

机构信息

Pediatric and Preventive Dentistry, Indira Gandhi Institute of Dental Sciences, Nellikuzhi, IND.

出版信息

Cureus. 2025 Jun 22;17(6):e86519. doi: 10.7759/cureus.86519. eCollection 2025 Jun.

DOI:10.7759/cureus.86519
PMID:40698209
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12281469/
Abstract

Gingival enlargement occurs secondary to the usage of anti-epileptics. The severity of overgrowth varies among different classes of drugs, with phenytoin having the highest incidence of reported cases, whereas cases associated with sodium valproate are minimal. Factors like drug dose, genetic factors, plaque, gingival inflammation, and periodontal health influence the degree of overgrowth. This case report presents one of the first surgically managed cases of generalized gingival enlargement in a pediatric patient due to chronic usage of sodium valproate.

摘要

牙龈增生继发于抗癫痫药物的使用。不同种类药物导致的增生严重程度各异，苯妥英钠报告病例的发生率最高，而丙戊酸钠相关病例极少。药物剂量、遗传因素、菌斑、牙龈炎症和牙周健康等因素会影响增生程度。本病例报告展示了首例因长期使用丙戊酸钠导致的小儿全身性牙龈增生并接受手术治疗的病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b05/12281469/a46570065af3/cureus-0017-00000086519-i07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b05/12281469/865257676696/cureus-0017-00000086519-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b05/12281469/4a442fa26098/cureus-0017-00000086519-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b05/12281469/7c854de38369/cureus-0017-00000086519-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b05/12281469/fe9f84ff8ece/cureus-0017-00000086519-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b05/12281469/f959bb1ddf40/cureus-0017-00000086519-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b05/12281469/ed28cb5d1801/cureus-0017-00000086519-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b05/12281469/a46570065af3/cureus-0017-00000086519-i07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b05/12281469/865257676696/cureus-0017-00000086519-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b05/12281469/4a442fa26098/cureus-0017-00000086519-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b05/12281469/7c854de38369/cureus-0017-00000086519-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b05/12281469/fe9f84ff8ece/cureus-0017-00000086519-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b05/12281469/f959bb1ddf40/cureus-0017-00000086519-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b05/12281469/ed28cb5d1801/cureus-0017-00000086519-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b05/12281469/a46570065af3/cureus-0017-00000086519-i07.jpg

相似文献

1
Sodium Valproate-Induced Gingival Enlargement in a Pediatric Patient: A Case Report With Surgical Intervention.丙戊酸钠致小儿牙龈增生：1例手术干预病例报告
Cureus. 2025 Jun 22;17(6):e86519. doi: 10.7759/cureus.86519. eCollection 2025 Jun.
2
Voclosporin-induced gingival enlargement: A case report.伏环孢素引起的牙龈增生：一例报告。
Clin Adv Periodontics. 2025 Jun 26. doi: 10.1002/cap.10369.
3
Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data.抗癫痫药物单药治疗癫痫：一项个体参与者数据的网络荟萃分析。
Cochrane Database Syst Rev. 2022 Apr 1;4(4):CD011412. doi: 10.1002/14651858.CD011412.pub4.
4
Comparison of two treatment modalities in the management of gingival enlargement during orthodontic treatment: a randomized clinical trial.正畸治疗期间牙龈增生管理中两种治疗方式的比较：一项随机临床试验。
Quintessence Int. 2025 Mar 18;56(3):226-235. doi: 10.3290/j.qi.b5809024.
5
Chlorhexidine mouthrinse as an adjunctive treatment for gingival health.洗必泰漱口水作为牙龈健康的辅助治疗方法。
Cochrane Database Syst Rev. 2017 Mar 31;3(3):CD008676. doi: 10.1002/14651858.CD008676.pub2.
6
Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data.癫痫的抗癫痫药物单药治疗：个体参与者数据的网状Meta分析
Cochrane Database Syst Rev. 2017 Jun 29;6(6):CD011412. doi: 10.1002/14651858.CD011412.pub2.
7
Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data.癫痫的抗癫痫药物单药治疗：个体参与者数据的网状荟萃分析
Cochrane Database Syst Rev. 2017 Dec 15;12(12):CD011412. doi: 10.1002/14651858.CD011412.pub3.
8
Phenytoin versus valproate monotherapy for partial onset seizures and generalized onset tonic-clonic seizures.苯妥英钠与丙戊酸单药治疗部分性发作和全面性强直阵挛发作的对比
Cochrane Database Syst Rev. 2001(4):CD001769. doi: 10.1002/14651858.CD001769.
9
Periodontal soft tissue non-root coverage procedures: a systematic review from the AAP Regeneration Workshop.牙周软组织非根面覆盖手术：来自美国牙周病学会再生研讨会的系统评价
J Periodontol. 2015 Feb;86(2 Suppl):S56-72. doi: 10.1902/jop.2015.130684.
10
Generalized gingival enlargement, periodontitis, and osteonecrosis of the jaw as manifestations of IgG4-related disease: A rare case report.以IgG4相关疾病表现为广泛性牙龈肿大、牙周炎和颌骨骨坏死：1例罕见病例报告
Medicine (Baltimore). 2025 Jul 11;104(28):e43260. doi: 10.1097/MD.0000000000043260.

本文引用的文献

1
Comparative Evaluation of Plaque Removal Effectiveness of Manual and Chewable Toothbrushes in Children: A Randomized Clinical Trial.儿童手动牙刷与可咀嚼牙刷菌斑清除效果的比较评估：一项随机临床试验
Int J Clin Pediatr Dent. 2019 Mar-Apr;12(2):107-110. doi: 10.5005/jp-journals-10005-1604.
2
Periodontal Management of Cyclosporin A-Induced Gingival Overgrowth: A Nonsurgical Approach.环孢素A诱导的牙龈增生的牙周管理：一种非手术方法。
Case Rep Dent. 2019 Apr 11;2019:8609547. doi: 10.1155/2019/8609547. eCollection 2019.
3
Dental plaque-induced gingival conditions.
牙菌斑引起的牙龈状况。
J Clin Periodontol. 2018 Jun;45 Suppl 20:S17-S27. doi: 10.1111/jcpe.12937.
4
Informational Paper: Drug-Associated Gingival Enlargement.信息文件：药物性牙龈增生
J Periodontol. 2004 Oct;75(10):1424-1431. doi: 10.1902/jop.2004.75.10.1424.
5
A Clinical Evaluation of Gingival Overgrowth in Children on Antiepileptic Drug Therapy.抗癫痫药物治疗儿童牙龈增生的临床评估
J Clin Diagn Res. 2016 Jan;10(1):ZC32-6. doi: 10.7860/JCDR/2016/16443.7069. Epub 2016 Jan 1.
6
Sodium valproate induced gingival enlargement in 22 months old child.丙戊酸钠导致一名22个月大儿童牙龈增生。
J Indian Soc Periodontol. 2014 Sep;18(5):644-7. doi: 10.4103/0972-124X.142465.
7
Phenytoin-induced gingival enlargement.苯妥英钠所致牙龈增生
BMJ Case Rep. 2014 May 28;2014:bcr2014204670. doi: 10.1136/bcr-2014-204670.
8
Global developmental delay with sodium valproate-induced gingival hyperplasia.全球发育迟缓伴丙戊酸钠诱导的牙龈增生。
BMJ Case Rep. 2014 Jan 22;2014:bcr2013200672. doi: 10.1136/bcr-2013-200672.
9
Drug-induced gingival overgrowth: The nemesis of gingiva unravelled.药物性牙龈增生：牙龈病变之谜揭晓。
J Indian Soc Periodontol. 2013 Mar;17(2):182-7. doi: 10.4103/0972-124X.113066.
10
Influence of mast cells in drug-induced gingival overgrowth.药物性牙龈增生中 mast cells 的影响。
Mediators Inflamm. 2013;2013:275172. doi: 10.1155/2013/275172. Epub 2013 Jan 28.