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全球发育迟缓伴丙戊酸钠诱导的牙龈增生。

Global developmental delay with sodium valproate-induced gingival hyperplasia.

作者信息

Patil Ravi B, Urs Pallavi, Kiran Shital, Bargale Seema Dinesh

机构信息

Department of Pedodontics and Preventive Dentistry, Rajiv Gandhi Dental College & Hospital, Bangalore, Karnataka, India.

出版信息

BMJ Case Rep. 2014 Jan 22;2014:bcr2013200672. doi: 10.1136/bcr-2013-200672.

DOI:10.1136/bcr-2013-200672
PMID:24451230
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3902317/
Abstract

Global developmental delay (GDD) refers to a disturbance in an individual child across one or more developmental domains, which include motor, cognition, daily activities, speech and language. The present case discusses a 5-year-old child with GDD associated with infantile spasms treated with sodium valproate. Delay in the widespread acquisition of skills, epilepsy and poor oral hygiene with gingival enlargement was the main concern to seek medical aid. This case is special as the child was suffering from GDD associated with sodium valproate-induced gingival enlargement.

摘要

全球发育迟缓(GDD)是指个体儿童在一个或多个发育领域出现障碍,这些领域包括运动、认知、日常活动、言语和语言。本病例讨论了一名5岁患有GDD并伴有婴儿痉挛症的儿童,使用丙戊酸钠进行治疗。技能广泛习得延迟、癫痫以及伴有牙龈增生的口腔卫生不良是寻求医疗帮助的主要问题。该病例较为特殊,因为患儿患有与丙戊酸钠引起的牙龈增生相关的GDD。

相似文献

1
Global developmental delay with sodium valproate-induced gingival hyperplasia.全球发育迟缓伴丙戊酸钠诱导的牙龈增生。
BMJ Case Rep. 2014 Jan 22;2014:bcr2013200672. doi: 10.1136/bcr-2013-200672.
2
Congenital gingival hyperplasia in a neonate with foetal valproate syndrome.一名患有胎儿丙戊酸盐综合征的新生儿出现先天性牙龈增生。
Neuropediatrics. 2007 Oct;38(5):251-2. doi: 10.1055/s-2007-985901.
3
Encephalopathy in an infant with infantile spasms: possible role of valproate toxicity.患有婴儿痉挛症患儿的脑病:丙戊酸盐毒性的潜在作用
BMJ Case Rep. 2014 Apr 15;2014:bcr2013200895. doi: 10.1136/bcr-2013-200895.
4
Gingival hyperplasia due to sodium valproate.丙戊酸钠所致牙龈增生
J Neurol Neurosurg Psychiatry. 1991 Mar;54(3):279-80. doi: 10.1136/jnnp.54.3.279-a.
5
Hyperplastic gingivitis in a child receiving sodium valproate treatment.一名接受丙戊酸钠治疗的儿童患增生性龈炎。
Proc Finn Dent Soc. 1979;75(5-6):95-8.
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Amlodipine induced gingival hyperplasia: a rare entity.氨氯地平引起的牙龈增生:一种罕见病症。
Int J Cardiol. 2007 Nov 30;122(3):e23-4. doi: 10.1016/j.ijcard.2006.11.066. Epub 2007 Feb 1.
7
[The enkorat treatment of infantile spasms and the Lennox-Gastaut syndrome].
Zh Nevrol Psikhiatr Im S S Korsakova. 1994;94(6):28-33.
8
Sodium valproate in the treatment of childhood epilepsies.丙戊酸钠治疗儿童癫痫
Indian Pediatr. 1984 Jun;21(6):439-46.
9
Remission of West syndrome associated with valproate hepatotoxicity.
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The effects of phenytoin and sodium valproate on the periodontal health of adult epileptic patients.苯妥英钠和丙戊酸钠对成年癫痫患者牙周健康的影响。
J Clin Periodontol. 1985 Jul;12(6):413-9. doi: 10.1111/j.1600-051x.1985.tb01377.x.

引用本文的文献

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Sodium Valproate-Induced Gingival Enlargement in a Pediatric Patient: A Case Report With Surgical Intervention.丙戊酸钠致小儿牙龈增生:1例手术干预病例报告
Cureus. 2025 Jun 22;17(6):e86519. doi: 10.7759/cureus.86519. eCollection 2025 Jun.
2
Global Developmental Delay in Children with Full Mouth Rehabilitation: A Case Series.全口义齿修复儿童的全球发育迟缓:病例系列
Int J Clin Pediatr Dent. 2023 May-Jun;16(3):522-527. doi: 10.5005/jp-journals-10005-2605.
3
Drug-induced gingival overgrowth: A critical insight into case reports from over two decades.药物性牙龈增生:对二十多年来病例报告的批判性洞察。
J Indian Soc Periodontol. 2016 Sep-Oct;20(5):496-502. doi: 10.4103/jisp.jisp_265_15.
4
Oral Health Characteristics and Dental Rehabilitation of Children with Global Developmental Delay.全球发育迟缓儿童的口腔健康特征与牙齿修复
Case Rep Dent. 2017;2017:5486327. doi: 10.1155/2017/5486327. Epub 2017 Jan 30.
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Sodium valproate induced gingival enlargement in 22 months old child.丙戊酸钠导致一名22个月大儿童牙龈增生。
J Indian Soc Periodontol. 2014 Sep;18(5):644-7. doi: 10.4103/0972-124X.142465.

本文引用的文献

1
Global developmental delay and mental retardation or intellectual disability: conceptualization, evaluation, and etiology.全球发育迟缓与智力迟钝或智力残疾:概念、评估及病因
Pediatr Clin North Am. 2008 Oct;55(5):1071-84, xi. doi: 10.1016/j.pcl.2008.07.010.
2
Effects of medications on the periodontal tissues in health and disease.药物对健康及患病时牙周组织的影响。
Periodontol 2000. 2006;40:120-9. doi: 10.1111/j.1600-0757.2005.00137.x.
3
Gingival enlargement in children treated with antiepileptics.接受抗癫痫药物治疗的儿童牙龈增生
J Child Neurol. 2004 Dec;19(12):958-63. doi: 10.1177/08830738040190120901.
4
Reported biomedical causes and associated medical conditions for mental retardation among 10-year-old children, metropolitan Atlanta, 1985 to 1987.1985年至1987年,亚特兰大大都市地区10岁儿童智力迟钝的报告生物医学原因及相关医疗状况。
Dev Med Child Neurol. 1997 Mar;39(3):142-9. doi: 10.1111/j.1469-8749.1997.tb07401.x.
5
Gingival enlargement induced by drugs.药物性牙龈增生
Drug Saf. 1996 Sep;15(3):219-31. doi: 10.2165/00002018-199615030-00007.