Hossain Md Sakhawat, Amin Md Al, Islam Sirajul, Imam Hasan, Das Liton Chandra, Mahmud Shahin
Department of Biotechnology and Genetic Engineering, Mawlana Bhashani Science and Technology University, Santosh, Tangail, Bangladesh.
Department of Biochemistry and Molecular Biology, Siddheswari College, Moghbazar, Dhaka, Bangladesh.
Microbiologyopen. 2025 Aug;14(4):e70034. doi: 10.1002/mbo3.70034.
The rapid rise in antibiotic resistance is a critical global health issue, and few new classes of antibiotics have been discovered since 1990 compared to the antibiotic's golden era between 1950 and 1970. However, developing new antimicrobial compounds faces many challenges, improvements in cultivation methods, genetic engineering, and advanced technologies are opening new paths for discovering and producing effective antibiotics. This study focuses on the fungal microbiome as a promising source of new antibiotics. We explored historical developments and advanced genetic techniques to reveal the potential of fungi in antibiotic production. Although isolating and scaling up fungal antibiotic production presents challenges, innovative approaches like in situ separation during fermentation can effectively address these issues. Our research highlights the importance of understanding fungal communication and metabolite sharing to enhance antibiotic yields and the connection of cutting-edge technologies in accelerating the discovery and optimization of antibiotic-producing fungi. By focusing on these technical aspects and fostering teamwork across various fields, this study aims to overcome current obstacles, and advance the development of antibiotic production technologies.
抗生素耐药性的迅速上升是一个关键的全球健康问题，与1950年至1970年的抗生素黄金时代相比，自1990年以来几乎没有发现新的抗生素类别。然而，开发新的抗菌化合物面临许多挑战，培养方法、基因工程和先进技术的改进为发现和生产有效的抗生素开辟了新途径。本研究聚焦于真菌微生物群，将其作为新抗生素的一个有前景的来源。我们探索了历史发展和先进的基因技术，以揭示真菌在抗生素生产中的潜力。尽管分离和扩大真菌抗生素生产存在挑战，但发酵过程中的原位分离等创新方法可以有效解决这些问题。我们的研究强调了理解真菌交流和代谢物共享以提高抗生素产量的重要性，以及前沿技术在加速发现和优化抗生素生产真菌方面的联系。通过关注这些技术方面并促进各领域之间的团队合作，本研究旨在克服当前障碍，推动抗生素生产技术的发展。
