Dévora-Figueroa Ana G, Estrada-Vargas Anaid, Burgess Jefferey L, Beamer Paloma I, Guillen-Rodríguez José M, García-Rico Leticia, Villa-Guillen Diana Evelyn, Mondaca-Fernández Iram, Meza-Montenegro Maria M
Programa de Doctorado en Ciencias Especialidad en Biotecnología, Instituto Tecnológico de Sonora, 5 de febrero 818 Sur, Ciudad Obregón 85000, Sonora, Mexico.
Community, Environment & Policy Department, Mel & Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ 85721, USA.
J Xenobiot. 2025 Jul 8;15(4):115. doi: 10.3390/jox15040115.
Arsenic exposure in children and adults has been associated with respiratory symptoms, respiratory infections, and decreased lung function. The goal of this study was to evaluate the relationship between environmental arsenic exposure and serum pneumoproteins and lung function. A cross-sectional study was conducted including 175 children exposed to arsenic by drinking water (range: 7.4 to 91 µg/L) and soil (range: 4.76 to 35.93 mg/kg), from some Yaqui villages. Arsenic was analyzed in dust and urine using field-portable X-ray fluorescence spectrometry and ICP/OES, respectively. Serum was analyzed for Clara Cell protein (CC16) and Matrix Metalloproteinase-9 (MMP-9) using immunoassays, and lung function was evaluated by spirometry. The results showed that increased arsenic in drinking water was associated with reduced forced expiratory volume in one second (FEV)/forced vital capacity (FVC) ratio (β = -0.027, = 0.0000) whereas, contrary to expectations, arsenic in dust was associated with increased FEV/FVC (β = 0.004, = 0.0076). Increased urinary arsenic was associated with reduced % predicted FEV (β = -0.723, = 0.0152) and reduced FEV/FVC ratio (β = -0.022, = 0.0222). Increased serum MMP-9 was associated with reduced FEV/FVC ratio (β = -0.017, = 0.0167). Children with % predicted FEV values less than 80 had the lowest levels of CC16 (Median 29.0 ng/mL, IQR 21.3, 37.4, = 0.0148). As a conclusion, our study evidenced an impairment in lung function in children exposed to low arsenic levels.
儿童和成人接触砷与呼吸道症状、呼吸道感染及肺功能下降有关。本研究的目的是评估环境砷暴露与血清肺保护蛋白及肺功能之间的关系。开展了一项横断面研究，纳入了来自一些亚基村庄的175名通过饮水（范围：7.4至91微克/升）和土壤（范围：4.76至35.93毫克/千克）接触砷的儿童。分别使用现场便携式X射线荧光光谱法和电感耦合等离子体/光学发射光谱法分析灰尘和尿液中的砷。使用免疫分析法分析血清中的克拉拉细胞蛋白（CC16）和基质金属蛋白酶-9（MMP-9），并通过肺活量测定法评估肺功能。结果显示，饮用水中砷含量增加与一秒用力呼气量（FEV）/用力肺活量（FVC）比值降低有关（β = -0.027，P = 0.0000），而与预期相反，灰尘中的砷与FEV/FVC增加有关（β = 0.004，P = 0.0076）。尿砷增加与预测FEV百分比降低（β = -0.723，P = 0.0152）和FEV/FVC比值降低（β = -0.022，P = 0.0222）有关。血清MMP-9增加与FEV/FVC比值降低有关（β = -0.017，P = 0.0167）。预测FEV值低于80%的儿童CC16水平最低（中位数29.0纳克/毫升，四分位间距21.3，37.4，P = 0.0148）。总之，我们的研究证明低砷暴露儿童存在肺功能损害。
