Pieczyńska A, Wasik-Olejnik A, Bobkiewicz T, Krawczak J
Pol J Pharmacol Pharm. 1985 May-Jun;37(3):429-35.
We compared the effects of low and high doses of dopamine and dobutamine (a synthetic catecholamine) on blood flow in relaxed or exercising muscles. Experiments were performed on rabbits. Blood flow in the muscles (calf) was estimated with the clearance method of radionuclide 133Xe. Dopamine and dobutamine were infused (iv) in doses of 20 or 40 micrograms/kg/min. Dopamine reduced muscle blood flow in resting state; this effect was more pronounced after higher doses. Dobutamine increased the flow; low doses were less effective. Dopamine may be an important determinant of the distribution of cardiac output to various vascular regions.
我们比较了低剂量和高剂量多巴胺及多巴酚丁胺（一种合成儿茶酚胺）对松弛或运动肌肉血流的影响。实验在兔子身上进行。采用放射性核素133Xe清除法估算肌肉（小腿）的血流。以20或40微克/千克/分钟的剂量静脉输注多巴胺和多巴酚丁胺。多巴胺降低静息状态下的肌肉血流；高剂量时这种作用更明显。多巴酚丁胺增加血流；低剂量效果较差。多巴胺可能是心输出量在不同血管区域分布的重要决定因素。
