Scott T, van der Zijpp A, Glick B
Poult Sci. 1985 Nov;64(11):2211-7. doi: 10.3382/ps.0642211.
Two experiments were conducted to examine the effects of feeding a diet containing .1% thiouracil to two lines of New Hampshire chickens differing in growth rate and relative bursa size. Body weight, serum 3,5,3'-triiodothyronine, and thyroxine were reduced by the thiouracil treatment. The primary total anti-sheep red blood cell (SRBC) titer in Experiment 1 was higher for thiouracil-fed (TF) chicks at 7 days postprimary immunization (PPI). In Experiment 2, the total anti-SRBC titers were higher for control chicks 3 days PPI; but from 5 to 10 days PPI, TF chicks had higher titers. During the secondary response in both experiments, the total anti-SRBC titers were not consistently higher for one dietary group over the other from 3 to 10 days postimmunization. Mercaptoethanol-resistant antibody titers were not significantly different between the two dietary groups in either experiment during the primary and secondary responses. Thiouracil-fed chicks had higher immunoglobulin G (IgG) and M (IgM) concentrations in serum during both the primary and secondary responses in Experiment 2. Although there was no genotype effect on antibody production to SRBC, serum immunoglobulins were different between lines. Small bursa line (SBL) chickens had higher serum IgG while the IgM concentrations of chicks from the Lester J. Dreesen strain were greater than those of SBL.
进行了两项实验，以研究给两系生长速度和法氏囊相对大小不同的新罕布什尔鸡饲喂含0.1%硫脲嘧啶的日粮所产生的影响。硫脲嘧啶处理降低了体重、血清3,5,3'-三碘甲状腺原氨酸和甲状腺素水平。在实验1中，初次免疫后7天，饲喂硫脲嘧啶（TF）的雏鸡的初次抗绵羊红细胞（SRBC）总滴度较高。在实验2中，初次免疫后3天，对照雏鸡的抗SRBC总滴度较高；但在初次免疫后5至10天，TF雏鸡的滴度较高。在两个实验的二次反应期间，从免疫后3至10天，一个日粮组的抗SRBC总滴度并不始终高于另一个日粮组。在初次和二次反应期间，两个日粮组的巯基乙醇抗性抗体滴度在两个实验中均无显著差异。在实验2的初次和二次反应期间，饲喂硫脲嘧啶的雏鸡血清中的免疫球蛋白G（IgG）和M（IgM）浓度较高。虽然对SRBC的抗体产生没有基因型效应，但品系之间的血清免疫球蛋白存在差异。小法氏囊系（SBL）鸡的血清IgG较高，而来自莱斯特·J·德雷森品系的雏鸡的IgM浓度高于SBL雏鸡。
