Hamdy Omar, Shetiwy Mosab, Saber Mahmoud M, Eldawody Basma A, Kassab Shorouq A, Nabih Mariam H, Abdelhakiem Mostafa, Zaki Mona, Yussif Shaimaa M, Saleh Saleh, Abdelwahab Khaled
Surgical Oncology Department, Oncology Center, Mansoura University, Mansoura, 35516, Egypt.
Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Discov Oncol. 2025 Jul 23;16(1):1396. doi: 10.1007/s12672-025-03146-2.
Mucinous (colloid) carcinoma (MC) of the breast typically affects postmenopausal and elderly women, with a more favorable prognosis compared to invasive breast carcinoma of no special type (IBC-NST). It is characterized by the presence of extracellular mucin and better outcomes. In our work, we presented a fifteen-year yield of a tertiary cancer center for MC.
In this retrospective study, the data of the patients with MC from January 2009 to August 2023 were retrieved by searching the prospectively registered electronic database of the Oncology Center, Mansoura University. The patients' epidemiological, clinical, pathological, therapeutic, and oncological data were analyzed.
A total of 152 patients with the pathology of MC of the breast were included. The mean age of patients was 55.38 ± 13.82 years. Imaging revealed a unifocal lesion in 93 patients (61.2%). The mean mass size by imaging was 37.25 ± 20.21 mm. Positive lymph nodes (LNs) were detected by imaging in 71 (46.7%) patients. Pathological variants were either pure MC (42.1%) or mixed mucinous ductal carcinoma (57.9%). Luminal A was the most common subtype. Neoadjuvant therapy (NAT) was received by 34.8% of the patients. Mastectomy was done for 103 patients (68.2%). Axillary lymph node dissection was done for 122 patients (80.3%), and sentinel lymph node biopsy (SLNB) was done for 30 patients (19.7%). Adjuvant chemotherapy and radiotherapy were received by 65.1% and 60.8% of patients, respectively, while adjuvant hormonal therapy was received by 84.5%. The mean disease-free survival (DFS) was 43 ± 34.02 months, while the mean overall survival (OAS) was 44.5 ± 33.46 months. Seventeen patients (11.2%) were reported dead during the follow-up period.
MC of the breast is a unique type of breast cancer. It may mimic benign lesions on imaging. The primary treatment for MC is mostly surgery, followed by adjuvant radiotherapy and systemic therapy. Comparing MC to IBC-NST, the former had a better prognosis and fewer lymphatic metastases, especially with pure MC, which shows a better prognosis.
乳腺黏液性（胶样）癌（MC）通常发生于绝经后及老年女性，与非特殊类型浸润性乳腺癌（IBC-NST）相比，其预后更佳。其特征为存在细胞外黏液且预后较好。在我们的研究中，我们展示了一家三级癌症中心15年的MC病例产出情况。
在这项回顾性研究中，通过检索曼苏拉大学肿瘤中心前瞻性注册的电子数据库，获取了2009年1月至2023年8月期间MC患者的数据。对患者的流行病学、临床、病理、治疗及肿瘤学数据进行了分析。
共纳入152例乳腺MC病理患者。患者的平均年龄为55.38±13.82岁。影像学检查显示93例患者（61.2%）为单发病变。影像学检查测得的平均肿块大小为37.25±20.21mm。影像学检查发现71例（46.7%）患者有阳性淋巴结（LNs）。病理类型为单纯MC（42.1%）或黏液性导管混合癌（57.9%）。Luminal A是最常见的亚型。34.8%的患者接受了新辅助治疗（NAT）。103例患者（68.2%）接受了乳房切除术。122例患者（80.3%）进行了腋窝淋巴结清扫，30例患者（19.7%）进行了前哨淋巴结活检（SLNB）。分别有65.1%和60.8%的患者接受了辅助化疗和放疗，而84.5%的患者接受了辅助激素治疗。平均无病生存期（DFS）为43±34.02个月，平均总生存期（OAS）为44.5±33.46个月。17例患者（11.2%）在随访期间死亡。
乳腺MC是一种独特类型的乳腺癌。它在影像学上可能类似良性病变。MC的主要治疗方法大多是手术，其次是辅助放疗和全身治疗。与IBC-NST相比，MC预后更好，淋巴转移更少，尤其是单纯MC，其预后更佳。
