Xiao Yuyang, Yang Yifei, Sun Binyu, Yang Meng, Lang Jiamiao, Dong Mintao, Chen Zengsihan, Chen Shanshan, Wang Shengfeng
Department of Pharmacy, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China.
Xiangya School of Medicine, Central South University, Changsha, China.
Front Microbiol. 2025 Jul 9;16:1618046. doi: 10.3389/fmicb.2025.1618046. eCollection 2025.
Fungal keratitis (FK) poses a significant public health challenge, causing substantial harm to human health and the socio-economic landscape. However, due to the special anatomical and physiological characteristics of the eye, the current therapeutic drugs for FK are not effective, which brings obstacles to the clinical treatment of FK. Nanomedicine is a new therapeutic method that has emerged in the field of FK therapy in recent years. On the one hand, nanomaterials can directly kill fungi by separating ions, and on the other hand, the drug delivery system (DDS) composed of nanomaterials can target and deliver traditional drugs to the affected area and play a bactericidal role, with a significantly higher effect than traditional therapy. This review begins with a bibliometric analysis of research progress in FK nanomedicine. Then we describe the mechanism and effect of various nanomedicine in the treatment of FK from the perspective of direct and indirect treatment, focusing on the attack of nanomedicine on biofilm and DDS composed of nanomaterials. Finally, this field is prospected in order to provide new insights and ideas for the development of FK nanomedicine.
真菌性角膜炎（FK）对公共卫生构成重大挑战，对人类健康和社会经济格局造成严重损害。然而，由于眼睛特殊的解剖和生理特性，目前用于治疗FK的药物效果不佳，这给FK的临床治疗带来了障碍。纳米医学是近年来在FK治疗领域出现的一种新的治疗方法。一方面，纳米材料可以通过分离离子直接杀死真菌，另一方面，由纳米材料组成的药物递送系统（DDS）可以将传统药物靶向递送至感染部位并发挥杀菌作用，其效果明显高于传统疗法。本综述首先对FK纳米医学的研究进展进行文献计量分析。然后，我们从直接治疗和间接治疗的角度描述了各种纳米医学在治疗FK中的作用机制和效果，重点关注纳米医学对生物膜的攻击以及由纳米材料组成的DDS。最后，对该领域进行了展望，以便为FK纳米医学的发展提供新的见解和思路。
