Carlton J, Rowland N
Pharmacol Biochem Behav. 1985 Oct;23(4):551-4. doi: 10.1016/0091-3057(85)90417-4.
The initial anorexia and development of tolerance to dl-fenfluramine was examined in rats with graded pretreatment body weight losses. Fenfluramine strongly attenuated food intake on the first test day in all weight groups and the magnitude of the initial anorexia did not differ between groups. The time course of anorectic tolerance was also similar in each of the groups. The results do not support a strict "set point" hypothesis according to which the tolerance to fenfluramine anorexia is an artifact of decreasing body weight and/or concurrently increasing relative food deprivation.
在经过分级预处理体重减轻的大鼠中，研究了对右芬氟拉明的初始厌食反应及耐受性的发展情况。在所有体重组中，芬氟拉明在首个测试日都强烈减少了食物摄入量，且各体重组之间初始厌食反应的程度并无差异。厌食耐受性的时间进程在每组中也相似。这些结果并不支持严格的“设定点”假说，即认为对芬氟拉明厌食的耐受性是体重下降和/或同时相对食物剥夺增加的一种假象。
