Joo Sae Kyung, Kim Won
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Seoul Metropolitan Government Boramae Medical Center, Seoul National University College of Medicine , Seoul, Korea.
Ewha Med J. 2024 Apr;47(2):e17. doi: 10.12771/emj.2024.e17. Epub 2024 Apr 30.
Understanding the effects of sex and sex differences on liver health and disease is crucial for individualized healthcare and informed decision-making for patients with liver disease. The impact of sex on liver disease varies according to its etiology. Women have a lower prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) than men. However, postmenopausal women face a higher risk of advanced liver fibrosis due to hormonal influences. Sex differences affect the pathogenesis of MASLD, which involves a complex process involving several factors such as hormones, obesity, and the gut microbiome. Furthermore, sex-related differences in the development of MASLDrelated hepatocellular carcinoma have been observed. The sex-specific characteristics of MASLD necessitate an individualized management approach based on scientific evidence. However, research in this area has been lacking. This article reviews the current understanding of sex differences in MASLD.
了解性别及性别差异对肝脏健康和疾病的影响，对于肝病患者的个性化医疗和明智决策至关重要。性别对肝病的影响因其病因而异。女性代谢功能障碍相关脂肪性肝病（MASLD）的患病率低于男性。然而，绝经后女性由于激素影响，面临晚期肝纤维化的风险更高。性别差异影响MASLD的发病机制，这是一个涉及激素、肥胖和肠道微生物群等多种因素的复杂过程。此外，在MASLD相关肝细胞癌的发生发展中也观察到了性别相关差异。MASLD的性别特异性特征需要基于科学证据的个性化管理方法。然而，该领域的研究一直缺乏。本文综述了目前对MASLD中性别差异的认识。
