Martini Chiara, Saeed Zeeba, Simeone Paola, Palma Stefano, Ricci Mirella, Arata Allegra, Sorella Anna, Liani Rossella, Ricci Fabrizio, D'Antonio Francesco, Mattioli Anna Vittoria, Gallina Sabina, Santilli Francesca, Renda Giulia
Department of Neuroscience, Imaging and Clinical Sciences, G. d'Annunzio University of Chieti-Pescara, Chieti, Italy.
Center for Advanced Studies and Technology, G. d'Annunzio University of Chieti-Pescara, Chieti, Italy.
Am J Prev Cardiol. 2025 Jul 3;23:101054. doi: 10.1016/j.ajpc.2025.101054. eCollection 2025 Sep.
Preeclampsia is a hypertensive disorder of pregnancy associated with significant maternal and fetal complications. Its pathogenesis involves endothelial dysfunction, abnormal placentation, and coagulation abnormalities, leading to increased thrombotic and hemorrhagic risks. This narrative review provides an in-depth overview of the pathophysiological mechanisms underlying preeclampsia, with a particular focus on its thrombotic and hemorrhagic complications. Treatment strategies are explored, with emphasis on the role of low-dose aspirin in reducing early-onset preeclampsia. However, aspirin's effectiveness varies based on dosage and timing, with higher doses showing greater benefit in preventing severe preeclampsia. Despite aspirin's widespread use, further optimization of its therapeutic role remains necessary to enhance maternal and fetal outcomes.
子痫前期是一种与严重母婴并发症相关的妊娠高血压疾病。其发病机制涉及内皮功能障碍、胎盘形成异常和凝血异常，导致血栓形成和出血风险增加。本叙述性综述深入概述了子痫前期的病理生理机制，特别关注其血栓形成和出血并发症。探讨了治疗策略，重点强调了低剂量阿司匹林在降低早发型子痫前期方面的作用。然而，阿司匹林的有效性因剂量和用药时间而异，较高剂量在预防重度子痫前期方面显示出更大益处。尽管阿司匹林被广泛使用，但仍有必要进一步优化其治疗作用，以改善母婴结局。
