Yamanouchi K, Arai Y
Physiol Behav. 1985 Aug;35(2):255-9. doi: 10.1016/0031-9384(85)90346-4.
Feminine sexual behaviors were tested in estradiol benzoate (EB) and progesterone (P) primed ovariectomized rats following four types of radiofrequency lesions in the midbrain tegmentum. The dorsomedial lesion (DML) which destroyed the ventromedial central gray including the dorsal raphe nucleus and adjacent area induced high sexual receptivity in the females primed with low dose (0.5 micrograms) of EB-P. All females with DML exhibited lordosis and ear wiggling, the mean lordosis quotient (LQ) being significantly higher than that of castrated controls or sham operated rats. Sexual receptivity in females with ventromedial tegmental lesion was not significantly different from those of the control and sham groups. In contrast to the medially lesioned groups, the mean LQ was low in the animals with bilateral lateral tegmental lesions even when the dose of EB was increased to 2 micrograms which was sufficient to induce high sexual receptivity in castrated and sham operated control females. In the animals with dorsolateral tegmental lesions (DLL), a much more severe loss of lordosis was seen than in those with ventrolateral tegmental lesions (VLL). None of the DLL females displayed sexual behavior throughout the present experiments. These results lead us to conclude that the midbrain dorsomedial tegmental area (ventral central gray and the adjacent area) is concerned with female sexual behavior inhibiting system, whereas the lateral tegmental area may be involved in the facilitatory system.
在对去卵巢大鼠用苯甲酸雌二醇（EB）和孕酮（P）进行预处理后，通过对中脑被盖进行四种类型的射频损伤，测试了雌性性行为。破坏包括背侧缝际核和相邻区域在内的腹内侧中央灰质的背内侧损伤（DML），能在低剂量（0.5微克）EB-P预处理的雌性大鼠中诱导出高性接受性。所有有DML的雌性大鼠均表现出脊柱前凸和耳朵摆动，平均脊柱前凸商（LQ）显著高于去势对照组或假手术大鼠。腹内侧被盖损伤的雌性大鼠的性接受性与对照组和假手术组无显著差异。与内侧损伤组相反，即使将EB剂量增加到2微克（足以在去势和假手术对照雌性大鼠中诱导高性接受性），双侧外侧被盖损伤的动物的平均LQ仍较低。在背外侧被盖损伤（DLL）的动物中，与腹外侧被盖损伤（VLL）的动物相比，脊柱前凸的丧失更为严重。在整个实验过程中，没有一只DLL雌性大鼠表现出性行为。这些结果使我们得出结论，中脑背内侧被盖区（腹侧中央灰质和相邻区域）与雌性性行为抑制系统有关，而外侧被盖区可能参与促进系统。
