病例报告：一名患有急性心包心肌炎以及伴有骨髓发育异常相关改变的急性髓系白血病的年轻女性。
Case report: A young woman with acute peri‑myocarditis and acute myeloid leukaemia with myelodysplasia-related changes.
作者信息
Szakács Zsolt, Habon Tamás, Kereskai László, Gopcsa László, Alizadeh Hussain
机构信息
Division of Hematology, First Department of Medicine, Medical School, University of Pécs, Pécs, Hungary.
Division of Cardiology, First Department of Medicine, Medical School, University of Pécs, Pécs, Hungary.
出版信息
Leuk Res Rep. 2025 Jul 10;24:100527. doi: 10.1016/j.lrr.2025.100527. eCollection 2025.
BACKGROUND
Clinical presentation in acute myeloid leukaemia (AML) can result in a wide variety of clinical phenotypes.
CASE REPORT
We report the case of a 34-year-old woman who presented with severe peri‑myocarditis and concomitant AML. The patient was treated with 5-azacitidine and venetoclax followed by haploidentical allogenic haematopoetic stem cell transplantation. Unfortunately, the patient developed febrile neutropenia and died because of overwhelming neutropenic sepsis. On autopsy, no evidence of AML was identified neither in bone marrow nor in cardiac tissue.
CONCLUSION
With this case report, we would like to emphasize the possibility of cardiac involvement in AML as well as the potential application of novel therapeutic agents in AML patients unfit for intensive chemotherapy.
背景
急性髓系白血病（AML）的临床表现可导致多种临床表型。
病例报告
我们报告了一名34岁女性的病例，她表现为严重的心包心肌炎并伴有AML。患者接受了阿扎胞苷和维奈克拉治疗，随后进行了单倍体异基因造血干细胞移植。不幸的是，患者发生了发热性中性粒细胞减少症，并因严重的中性粒细胞减少性败血症死亡。尸检时，在骨髓和心脏组织中均未发现AML的证据。
结论
通过本病例报告，我们想强调AML累及心脏的可能性以及新型治疗药物在不适合强化化疗的AML患者中的潜在应用。
Zotero 插件