Karti Omer, Ayhan Ziya, Saatci Osman Ali
Cesk Slov Oftalmol. 2025;81(Ahead of Print):1-9. doi: 10.31348/2025/26.
Vogt-Koyanagi-Harada (VKH) disease is an autoimmune disorder affecting multiple systems and characterized by bilateral granulomatous uveitis, frequently together with neurological, auditory, and integumentary manifestations. Prompt diagnosis and intervention are a must to prevent irreversible vision loss and possible systemic complications. Fundus imaging plays a pivotal role in the management of VKH, not only to reach the diagnosis but also to monitor disease activity and response to treatment. Fundus photography, fundus autofluorescence imaging, fluorescein angiography, indocyanine green angiography, and optical coherence tomography (OCT) are among the imaging modalities. These methods provide invaluable insights into the different phases of the disease. In addition, OCT angiography enables clinicians to visualize associated retinal and choroidal microvascular changes. Continuous advances in imaging technology assist ophthalmologists to comprehend the VKH pathophysiology and to facilitate its differential diagnosis. Thus, clinical outcomes are improving with timely interventions and personalized treatment approaches. This mini-review provides an overview of VKH disease, with a particular focus on the fundus imaging techniques utilized in its management.
伏格特-小柳-原田（VKH）病是一种影响多个系统的自身免疫性疾病，其特征为双侧肉芽肿性葡萄膜炎，常伴有神经、听觉和皮肤表现。及时诊断和干预对于预防不可逆的视力丧失和可能的全身并发症至关重要。眼底成像在VKH的治疗中起着关键作用，不仅有助于诊断，还能监测疾病活动和对治疗的反应。眼底摄影、眼底自发荧光成像、荧光素血管造影、吲哚菁绿血管造影和光学相干断层扫描（OCT）等均属于成像方式。这些方法为疾病的不同阶段提供了宝贵的见解。此外，OCT血管造影使临床医生能够观察到相关的视网膜和脉络膜微血管变化。成像技术的不断进步有助于眼科医生理解VKH的病理生理学并促进其鉴别诊断。因此，通过及时干预和个性化治疗方法，临床结果正在改善。本综述概述了VKH病，特别关注其治疗中使用的眼底成像技术。
