Lin Weihong, Hill Thomas, Stroup Andrea M, Sarles Samantha Emma, Ogura Tatsuya, Augustine Farhan, O'Sullivan Sean, Rahman Irfan, Robinson Risa, Jabba Sairam V, Nuss Caleb, Hensel Edward
Department of Biological Sciences, University of Maryland Baltimore County, Baltimore, MD 21250, United States.
Division of Nonclinical Science, Center for Tobacco Products, U.S. Food and Drug Administration, Silver Spring, MD 20993, United States.
Toxicol Sci. 2025 Oct 1;207(2):272-288. doi: 10.1093/toxsci/kfaf091.
The toxicologic impacts on the normative function of the chemosensory system and the loss of its contribution to organism protection and homeostasis remain an underrepresented area of interest in the published literature. The impact of chemical constituents in electronic nicotine delivery system e-liquids or aerosols on the chemosensory system is even less known, as are the effects on product selection and use behavior-and this may be an overlooked impact on the public health. This review is a snapshot of the current state of the science and opportunities for improving and increasing the volume of publications in chemosensory toxicology on the potential impacts of tobacco products. The proposed solutions rely on the determination of the scientific community to take advantage of an unexplored field of opportunity. Active research engagement and use of an integrative, risk-driven planning framework to address harmonization and data gaps in neurosensory research programs would support harmonization, improve scientific visibility in the published literature, and recruit additional investigators to this research community.
化学感应系统正常功能受到的毒理学影响以及该系统对机体保护和内稳态贡献的丧失，在已发表文献中仍是一个未得到充分关注的研究领域。电子尼古丁传送系统电子烟液或气溶胶中的化学成分对化学感应系统的影响，以及对产品选择和使用行为的影响，更是鲜为人知——而这可能是对公众健康的一种被忽视的影响。本综述概述了化学感应毒理学领域的当前科学状况，以及增加关于烟草产品潜在影响的出版物数量和改进相关研究的机会。所提出的解决方案依赖于科学界利用这一尚未探索的机会领域的决心。积极开展研究，并使用综合的、风险驱动的规划框架来解决神经感觉研究项目中的协调问题和数据缺口，将有助于实现协调一致，提高在已发表文献中的科学能见度，并吸引更多研究人员加入这个研究群体。
