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[实体瘤克隆源性细胞的辐射反应。小鼠NKLy实体瘤的克隆形成能力及其氧状态]

[Radiation response of clonogenic cells of solid tumors. Clonogenic capacity of the murine NKLy solid tumor and its oxygen status].

作者信息

Gulverdashvili N A, Afanas'ev G G, Kir'ianov I Iu, Chizhov A Ia, Pelevina I I

出版信息

Radiobiologiia. 1985 Sep-Oct;25(5):661-4.

PMID:4070573
Abstract

Clonogenic capacity and oxygen tension were determined in peripheral and central zones of solid tumors NKLy in vivo. With low pO2 in central zones (2.69 +/- 0.60 as opposed to 4.64 +/- 0.68 mm m. c. in peripheral zones) and in the presence of anoxic sites, the effectiveness of cloning, with inoculation immediately after isolation of cells from central zones, did not differ from that from peripheral ones (6.36 +/- 0.45 and 6.78 +/- 0.68%, respectively).

摘要

在体内对实体瘤NKLy的外周和中心区域测定克隆形成能力和氧张力。中心区域的氧分压较低(2.69±0.60,而外周区域为4.64±0.68毫米汞柱)且存在缺氧部位,在从中心区域分离细胞后立即接种时,克隆的有效性与外周区域的无差异(分别为6.36±0.45%和6.78±0.68%)。

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