Kebbe Maryam, Falkenhain Kaja, Beyl Robbie, Altazan Abby D, Flanagan Emily W, Kracht Chelsea L, Cabre Hannah E, Woolf Emily K, Hsia Daniel S, Apolzan John W, Redman Leanne M
Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA.
Faculty of Kinesiology, University of New Brunswick, Fredericton, New Brunswick, Canada.
Obesity (Silver Spring). 2025 Sep;33(9):1680-1693. doi: 10.1002/oby.24357. Epub 2025 Jul 24.
To examine the effects of a pragmatic multicomponent eHealth intervention in pregnancy on body composition changes and subsequent associations with perinatal outcomes.
Pregnant individuals (n = 351) enrolled in Louisiana's Women, Infants, and Children program were randomly assigned to a multicomponent eHealth Intervention or Usual Care. Fat percentage, fat mass, and fat-free mass were assessed using bioelectrical impedance at trimester-specific study visits. Mixed models evaluated within- and between-group differences in body composition from early to late pregnancy: overall, by BMI, and by gestational weight gain (GWG) guideline attainment. Effects of body composition changes on perinatal outcomes was evaluated.
Compared to Usual Care (n = 172), the Intervention Group (n = 179) had attenuated gains in fat mass, fat mass index, and fat percentage from early to late pregnancy overall, in individuals who had normal weight at enrollment, and in those who exceeded GWG guidelines (p < 0.05). No significant between-group differences in fat-free mass were observed. Fat mass change interacted with intervention effects on neonatal health outcomes (p = 0.01).
Lifestyle interventions during pregnancy may attenuate gestational fat mass gain, particularly among women with normal weight and those who exceed GWG guidelines, with potential implications for neonatal health outcomes.
ClinicalTrials.gov identifier: NCT04028843.
研究一种实用的多成分电子健康干预措施对孕期身体成分变化及其与围产期结局后续关联的影响。
纳入路易斯安那州妇女、婴儿和儿童项目的孕妇（n = 351）被随机分配至多成分电子健康干预组或常规护理组。在特定孕期的研究访视中，使用生物电阻抗法评估脂肪百分比、脂肪量和去脂体重。混合模型评估从孕早期到孕晚期身体成分的组内和组间差异：总体情况、按体重指数（BMI）以及按孕期体重增加（GWG）指南达标情况进行评估。评估身体成分变化对围产期结局的影响。
与常规护理组（n = 172）相比，干预组（n = 179）在总体上、入组时体重正常的个体以及超过GWG指南的个体中，从孕早期到孕晚期的脂肪量、脂肪量指数和脂肪百分比增加有所减缓（p < 0.05）。未观察到组间去脂体重有显著差异。脂肪量变化与干预对新生儿健康结局的影响存在交互作用（p = 0.01）。
孕期的生活方式干预可能会减缓孕期脂肪量的增加，尤其是在体重正常的女性和超过GWG指南的女性中，这可能对新生儿健康结局产生潜在影响。
ClinicalTrials.gov标识符：NCT04028843。
