Domingo J L, Paternain J L, Llobet J M, Corbella J
Rev Esp Fisiol. 1985 Sep;41(3):293-8.
Four groups of pregnant Wistar rats, each of which consisted of 15 animals were administered 0, 12, 14 and 48 mg/kg/day of cobalt (II) chloride from the 14th day of gestation through 21 days of lactation. The offspring were observed for mortality, body weight, body and tail length and general symptomatology after 1, 4 and 21 days of nursing. The number of litters was higher for the control group. The survival ratios were also higher for the control group. Besides, a dose-dependent delay in the growth of the living young could be observed. No significant differences in organ weights in the animals killed 21 days after birth were observed. The blood parameters analysed did not show differences between the treated and control pups. Cobalt produced toxic effects on the mothers, affecting the late gestation as well as the postnatal development of the pups.
将四组妊娠的Wistar大鼠（每组15只）从妊娠第14天至哺乳期第21天分别给予0、12、14和48毫克/千克/天的氯化钴（II）。在哺乳1、4和21天后观察后代的死亡率、体重、体长和尾长以及一般症状。对照组的窝数较多。对照组的存活率也较高。此外，可以观察到存活幼崽的生长存在剂量依赖性延迟。在出生21天后处死的动物中，未观察到器官重量有显著差异。所分析的血液参数在经处理的幼崽和对照幼崽之间未显示出差异。钴对母鼠产生了毒性作用，影响了妊娠后期以及幼崽的产后发育。
