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Live vaccine development through targeted protein degradation.

作者信息

Zhang Qisi, Si Longlong

机构信息

State Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.

University of Chinese Academy of Sciences, Beijing, China.

出版信息

Nat Rev Immunol. 2025 Jul 24. doi: 10.1038/s41577-025-01212-y.

DOI:10.1038/s41577-025-01212-y
PMID:40707692
Abstract
摘要

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Mechanism of capsaicin entry into buried vanilloid sites in TRPV1.辣椒素进入TRPV1中埋藏的香草酸位点的机制。
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Proteolysis-targeting influenza vaccine strains induce broad-spectrum immunity and in vivo protection.蛋白酶靶向流感疫苗株可诱导广谱免疫和体内保护。
Nat Microbiol. 2025 Feb;10(2):431-447. doi: 10.1038/s41564-024-01908-2. Epub 2025 Jan 15.
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Generation of a live attenuated influenza A vaccine by proteolysis targeting.通过蛋白水解靶向技术生成活流感疫苗。
Nat Biotechnol. 2022 Sep;40(9):1370-1377. doi: 10.1038/s41587-022-01381-4. Epub 2022 Jul 4.