Mazzoleni Felipe, de Mendonça Uchoa Diego, Mazzoleni Luiz Edmundo, de Magalhães Francesconi Carlos Fernando, Milbradt Tobias Cancian, da Silva Ries Sacha Allebrandt, Fernandes Alexandra Cauduro Ponso, Schaefer Pedro Guilherme, Golbspan Liane, Breyer Helenice Pankowski, Michalczuk Matheus Truccolo, Ott Eduardo André, Simon Daniel, Talley Nicholas J
Postgraduate Program Sciences in Gastroenterology and Hepatology, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Department of Internal Medicine, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
Dig Dis Sci. 2025 Jul 24. doi: 10.1007/s10620-025-09229-y.
PURPOSE: Duodenal eosinophils have been associated with functional dyspepsia, but its association with Helicobacter pylori (H. pylori) remains unclear. Our aim was to investigate the connection between eosinophils in duodenal villi and dyspeptic symptoms, as well as its association with H. pylori infection. METHODS: We evaluated 100 functional dyspeptic patients, 50 H. pylori positive and 50 H. pylori negative, all meeting Rome III criteria. Participants underwent upper gastrointestinal endoscopy with gastric and duodenal biopsies. Duodenal villi eosinophil were counted in 5 random high-power fields (HPF). We evaluated the association between duodenal villi eosinophils and dyspeptic symptoms using the validated PADYQ questionnaire. Duodenal villi eosinophils were also compared between H. pylori-positive and -negative groups and analyzed according to demographic and endoscopic variables. RESULTS: Patients were predominantly female (88%) with a mean age of 41.8 years. Median eosinophil/HPF in duodenal villi were 4.6 [2.8-7.2] in H. pylori negative and 4.7 [3.4-8.4] in H. pylori positive subjects (p = 0.40). Duodenal villi eosinophil increased with symptom severity: 3.4 [2.2-6.0] for mild, 4.7 [3.2-6.4] for moderate and 5.8 [3.6-8.2] for severe symptoms (p = 0.03). Multivariate analysis showed that duodenal villi eosinophils were independently associated with smoking (p = 0.02) and symptom severity (p = 0.04). CONCLUSION: Duodenal villi eosinophils did not correlate with H. pylori infection but was associated with dyspepsia symptoms severity.
目的：十二指肠嗜酸性粒细胞与功能性消化不良有关，但其与幽门螺杆菌（H. pylori）的关系仍不清楚。我们的目的是研究十二指肠绒毛中的嗜酸性粒细胞与消化不良症状之间的联系，以及其与幽门螺杆菌感染的关系。 方法：我们评估了100名功能性消化不良患者，其中50名幽门螺杆菌阳性，50名幽门螺杆菌阴性，所有患者均符合罗马III标准。参与者接受了上消化道内窥镜检查及胃和十二指肠活检。在5个随机高倍视野（HPF）中计数十二指肠绒毛嗜酸性粒细胞。我们使用经过验证的PADYQ问卷评估十二指肠绒毛嗜酸性粒细胞与消化不良症状之间的关联。还比较了幽门螺杆菌阳性和阴性组之间的十二指肠绒毛嗜酸性粒细胞，并根据人口统计学和内窥镜变量进行分析。 结果：患者以女性为主（88%），平均年龄为41.8岁。幽门螺杆菌阴性患者十二指肠绒毛嗜酸性粒细胞/HPF的中位数为4.6[2.8 - 7.2]，幽门螺杆菌阳性患者为4.7[3.4 - 8.4]（p = 0.40）。十二指肠绒毛嗜酸性粒细胞随症状严重程度增加：轻度症状患者为3.4[2.2 - 6.0]，中度症状患者为4.7[3.2 - 6.4]，重度症状患者为5.8[3.6 - 8.2]（p = 0.03）。多变量分析显示，十二指肠绒毛嗜酸性粒细胞与吸烟（p = 0.02）和症状严重程度（p = 0.04）独立相关。 结论：十二指肠绒毛嗜酸性粒细胞与幽门螺杆菌感染无关，但与消化不良症状严重程度有关。
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