Opportunities and challenges for hepatitis B cure in people living with HIV and hepatitis B virus.
作者信息
Singh Kasha P, Audsley Jennifer, Zhao Wei, Lewin Sharon R
机构信息
Victorian Infectious Diseases Service, Royal Melbourne Hospital at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
Department of Infectious Diseases, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
出版信息
J Int AIDS Soc. 2025 Jul;28(7):e70015. doi: 10.1002/jia2.70015.
Abstract
摘要
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本文引用的文献
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EASL Clinical Practice Guidelines on the management of hepatitis B virus infection.欧洲肝脏研究学会关于乙型肝炎病毒感染管理的临床实践指南。
J Hepatol. 2025 Aug;83(2):502-583. doi: 10.1016/j.jhep.2025.03.018. Epub 2025 May 10.
3
Early antiviral treatment with tenofovir alafenamide to prevent serious clinical adverse events in adults with chronic hepatitis B and moderate or high viraemia (ATTENTION): interim results from a randomised controlled trial.使用丙酚替诺福韦进行早期抗病毒治疗以预防慢性乙型肝炎且病毒血症为中度或高度的成人发生严重临床不良事件（ATTENTION）：一项随机对照试验的中期结果
Lancet Gastroenterol Hepatol. 2025 Apr;10(4):295-305. doi: 10.1016/S2468-1253(24)00431-X. Epub 2025 Feb 3.
4
Phase Ib/IIa randomized study of heterologous ChAdOx1-HBV/MVA-HBV therapeutic vaccination (VTP-300) as monotherapy and combined with low-dose nivolumab in virally-suppressed patients with CHB.一项异源 ChAdOx1-HBV/MVA-HBV 治疗性疫苗（VTP-300）作为单药治疗以及与低剂量纳武利尤单抗联合治疗在慢性乙型肝炎病毒抑制患者中的 Ib/IIa 期随机研究。
J Hepatol. 2024 Dec;81(6):949-959. doi: 10.1016/j.jhep.2024.06.027. Epub 2024 Jul 6.
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Gut Liver. 2024 Jul 15;18(4):593-601. doi: 10.5009/gnl240023. Epub 2024 Mar 27.
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Safety and efficacy of the oral TLR8 agonist selgantolimod in individuals with chronic hepatitis B under viral suppression.在病毒抑制的慢性乙型肝炎个体中口服 TLR8 激动剂 selgantolimod 的安全性和疗效。
J Hepatol. 2023 Mar;78(3):513-523. doi: 10.1016/j.jhep.2022.09.027. Epub 2022 Oct 29.
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Design and analysis considerations for early phase clinical trials in hepatitis B (HBV) cure research: the ACTG A5394 study in persons with both HIV and HBV.乙型肝炎（HBV）治愈研究早期临床试验的设计与分析考量：针对合并感染HIV和HBV患者的ACTG A5394研究
J Virus Erad. 2023 Aug 24;9(3):100344. doi: 10.1016/j.jve.2023.100344. eCollection 2023 Sep.
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