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一例通过宏基因组下一代测序确诊的艾滋病合并混合性肺部感染病例报告。

A case report of AIDS complicated by and mixed pulmonary infection identified via metagenomic next-generation sequencing.

作者信息

Sun Xiaokui, Gong Qiangjin

机构信息

Department of Respiratory and Critical Care Medicine, Hangzhou Linping Hospital of Traditional Chinese Medicine, Hangzhou, China.

Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, China.

出版信息

Front Med (Lausanne). 2025 Jul 10;12:1599261. doi: 10.3389/fmed.2025.1599261. eCollection 2025.

Abstract

is a Gram-positive bacterium that is rarely encountered in clinical practice. It primarily affects the digestive and nervous systems, with pulmonary infections being infrequently reported. This case report describes a patient with HIV/AIDS who developed a mixed pulmonary infection involving and . The diagnosis was confirmed via metagenomic next-generation sequencing (mNGS) of bronchoalveolar lavage fluid obtained through bronchoscopy. Following appropriate treatment, the patient's symptoms and pulmonary imaging findings showed marked improvement.

摘要

是一种革兰氏阳性菌,在临床实践中很少见。它主要影响消化系统和神经系统,肺部感染的报道较少。本病例报告描述了一名艾滋病毒/艾滋病患者发生了涉及[具体细菌名称1]和[具体细菌名称2]的混合性肺部感染。通过对经支气管镜检查获得的支气管肺泡灌洗 fluid进行宏基因组下一代测序(mNGS)确诊。经过适当治疗,患者的症状和肺部影像学表现有明显改善。 (注:原文中“involving and ”处具体细菌名称缺失,翻译时按原文保留)

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4471/12287093/242799027762/fmed-12-1599261-g001.jpg

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