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内源性/外源性抗氧化剂水平与1型和2型糖尿病及其三种并发症风险之间的双向因果关联

Bidirectional Causal Associations Between Endogenous/Exogenous Antioxidant Levels and Risks of Type 1 and Type 2 Diabetes Mellitus and Three Complications.

作者信息

Shen Liang, Meng Lei, Ji Hong-Fang

机构信息

Institute of Food and Drug Research for One Health, School of Food Engineering Ludong University Yantai People's Republic of China.

School of Life Sciences and Medicine Shandong University of Technology Zibo People's Republic of China.

出版信息

Food Sci Nutr. 2025 Jul 24;13(7):e70671. doi: 10.1002/fsn3.70671. eCollection 2025 Jul.

DOI:10.1002/fsn3.70671
PMID:40708774
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12288615/
Abstract

Owing to the significant pathogenic role played by oxidative stress in diabetes mellitus, the associations between antioxidants and the incidence of diabetes mellitus have garnered much interest, while the findings are conflicting. The present study aimed to investigate the bidirectional causal connections underlying the relationship between circulating levels of eight endogenous and five exogenous antioxidants and the risks of type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM), as well as three complications: diabetic ketoacidosis, diabetic nephropathy, and diabetic retinopathy, by means of Mendelian randomization analyses. The analyses indicate that albumin and bilirubin may causally contribute to protection against the development of T1DM and T2DM, respectively. The exogenous β-carotene is likely to act as a protective factor against the development of T2DM. Bilirubin may have a causally protective role in preventing the development of diabetic ketoacidosis. For the reverse analysis of diseases predicting antioxidant levels, T1DM, T2DM, and their complications were likely to be associated with varied levels of several antioxidants, but the effects are weak overall. Our analyses may provide useful clues that inform the use of antioxidants for preventing or predicting both diabetes mellitus and its complications.

摘要

由于氧化应激在糖尿病中发挥着重要的致病作用，抗氧化剂与糖尿病发病率之间的关联已引起广泛关注，但其研究结果相互矛盾。本研究旨在通过孟德尔随机化分析，探究八种内源性和五种外源性抗氧化剂的循环水平与1型糖尿病（T1DM）、2型糖尿病（T2DM）风险以及三种并发症（糖尿病酮症酸中毒、糖尿病肾病和糖尿病视网膜病变）之间关系的双向因果联系。分析表明，白蛋白和胆红素可能分别对预防T1DM和T2DM的发生具有因果作用。外源性β-胡萝卜素可能是预防T2DM发生的保护因素。胆红素在预防糖尿病酮症酸中毒的发生方面可能具有因果保护作用。对于预测抗氧化剂水平的疾病反向分析，T1DM、T2DM及其并发症可能与几种抗氧化剂的不同水平相关，但总体影响较弱。我们的分析可能为使用抗氧化剂预防或预测糖尿病及其并发症提供有用线索。

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本文引用的文献

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Heme oxygenase, biliverdin reductase, and bilirubin pathways regulate oxidative stress and insulin resistance: a focus on diabetes and therapeutics.血红素加氧酶、胆绿素还原酶和胆红素途径调节氧化应激和胰岛素抵抗：聚焦糖尿病与治疗学
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