Li Liu-Cheng, Zhang Su, Sun Jia-Bin, Xu Yao-Yao, Mao Kai-Li
Department of Pharmacy, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Department of Pharmacy, Center for Clinical Pharmacy, Cancer Center, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Front Cardiovasc Med. 2025 Jul 10;12:1512784. doi: 10.3389/fcvm.2025.1512784. eCollection 2025.
Clinical pharmacists supported clinicians in medication planning and health education for a male patient diagnosed with hypertrophic cardiomyopathy (HCM). Therapeutically, diltiazem was replaced with metoprolol to further alleviate symptoms. Whole-blood exon sequencing revealed a pathogenic mutation in the beta-myosin heavy chain gene (MYH7, OMIM #160760), consistent with dominant inheritance. Furthermore, low-intensity exercise and screening of the patient's children were recommended. In addition, we provided an overview of current therapeutic approaches, emphasizing potential novel agents and non-pharmaceutical interventions for HCM management. This is the first case report to highlight not only updates in HCM treatment but also the pharmacist's role in long-term HCM management.
临床药师为一名被诊断为肥厚型心肌病（HCM）的男性患者提供了药物治疗规划和健康教育方面的支持。在治疗上，用美托洛尔替代了地尔硫卓以进一步缓解症状。全血外显子测序显示β-肌球蛋白重链基因（MYH7，OMIM #160760）存在致病突变，符合显性遗传。此外，建议进行低强度运动并对患者的子女进行筛查。另外，我们概述了当前的治疗方法，强调了用于HCM管理的潜在新型药物和非药物干预措施。这是首例不仅突出HCM治疗进展，还凸显药师在HCM长期管理中作用的病例报告。
